The overarching goal of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK-IDDRC) is to improve the lives of children with intellectual and developmental disabilities through research and clinical outreach. Forty years of distinguished history in basic research and clinical care as one ofthe flagship IDDRCs of NICHD, coupled with important recent faculty recruitments and facility developments at Einstein have, in concert, sown the seeds of a rennaissance in the Kennedy Center IDD program. Critical to this process is a new Kennedy Center leadership team providing a vision of cooperation and collaboration whereby bench scientists and clinicians work intertwined toward the common goal of translating studies in simple systems to clinical insight and therapies with direct relevance to patient health. Four research themes embodying both the basic science strengths at Einstein and critical IDD-related clinical issues inherent in the Bronx and surrounding populations have been identified, as have key scientific cores essential for supporting research advances in these areas. Research themes are focused on the overlapping and ail-important areas of Autism Spectrum Disorders, Neurogenetic and Seizure Disorders, Nutritional and Environmental Determinants of Brain Development, and Deafness and Communication Disorders. Six scientific cores are designed to provide the means for both human and animal phenotyping, neuron and whole brain imaging, cell and tissue manipulation, and genetic analyses, with each centered strategically to provide advancements in bench research and patient care. Partners in this effort include the powerful research engines of Neuroscience and Genetics and other key academic departments at Einstein along with the Kennedy Center's clinical affiliates - the Children's Evaluation and Rehabiltiation Center (CERC) and the Children's Hospital At Montefiore (CHAM). These clinical centers and their contributing clinical departments serve one of the neediest urban populations in the country, where intellectual and developmental disabilities occur in economically deprived, and underserved racially-mixed minority populations. These remarkable research and clincial resources, coupled with a reinvorgorate and inspired leadership and program, provide the basis for a new era for the Rose F. Kennedy Center as it strives toward its goal of improving the lives of children with intellectual and developmental disabilities.

Public Health Relevance

Intellectual and Developmental Disabilities (IDD) represent one of the most significant categories of health impact involving children, affecting hundreds of thousands of individuals in the US alone. The purpose of this proposal is to establish an IDD research center, the Rose F. Kennedy IDDRC, as a means to promote a program of cutting-edge scientific and translational research in neuroscience and genetics coupled with dedicated, indepth clinical efforts focused on diagnosis and patient care.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD071593-03
Application #
8507783
Study Section
Special Emphasis Panel (ZHD1-DSR-Y (50))
Program Officer
Parisi, Melissa
Project Start
2011-09-26
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$1,070,881
Indirect Cost
$531,640
Name
Albert Einstein College of Medicine
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Boudewyn, Lauren C; Sikora, Jakub; Kuchar, Ladislav et al. (2017) N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV. Neurobiol Dis 105:257-270
Pera, Marta; Larrea, Delfina; Guardia-Laguarta, Cristina et al. (2017) Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. EMBO J 36:3356-3371
Melentijevic, Ilija; Toth, Marton L; Arnold, Meghan L et al. (2017) C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature 542:367-371
Kikusui, Takefumi; Hiroi, Noboru (2017) A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism. Neuropsychopharmacology 42:378
Saied-Santiago, Kristian; Townley, Robert A; Attonito, John D et al. (2017) Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans. Genetics 206:1951-1967
Ray, Alex K; DuBois, Juwen C; Gruber, Ross C et al. (2017) Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure. Glia 65:2051-2069
Zheng, Chaogu; Diaz-Cuadros, Margarete; Nguyen, Ken C Q et al. (2017) Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. Mol Biol Cell 28:2786-2801
Wang, Ping; Mokhtari, Ryan; Pedrosa, Erika et al. (2017) CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells. Mol Autism 8:11
Thomsen, Anna M; Gulinello, Maria E; Wen, Jing et al. (2017) Liposomal Cytarabine Induces Less Neurocognitive Dysfunction Than Intrathecal Methotrexate in an Animal Model. J Pediatr Hematol Oncol :
Sikora, Jakub; Dworski, Shaalee; Jones, E Ellen et al. (2017) Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. Am J Pathol 187:864-883

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