The goal of the Neurogenomics Core is to provide the most advanced genomics and epigenomics assays and analyses to support the neurological and neuroscience research goals of the IDDRC community at the RFK-IDDRC. Modern neuroscience and neurology research has an increasing need for sophisticated genome-wide genetic and epigenetic assays in the quest to understand not only disease states but also the normal functioning of the nervous system. With the goals for the IDDRC encompassing areas such as the study of the pathogenesis of autism, the links between nutrition, obesity and brain development, deafness and communication disorders, and the pathogenesis of neurogenetic disorders, both genetic and epigenetic influences are obvious potential factors that must be considered. A strong cutting-edge Neurogenomics Core that supplies access to the most up-to-date sophisticated genomic technologies in a cost-effective and efficient manner is therefore an essential resource within a Center such as this. We will describe how we have assembled, integrated and extended resources across a system of existing core facilities to serve the specific neurogenetic needs of the IDDRC community at Einstein, leveraging the investment of the IDDRC to provide a powerful integrated readily accessible core facility that allows even the most inexperienced users to perform studies productively and successfully. The resources to be assembled are from multiple existing core facilities at Einstein, all developed and run by the Department of Genetics and the Center for Epigenomics. The leadership for this core is drawn from both of these entities, reflecting their commitment to the success of this core within the IDDRC. The Neurogenomics Core Facility will serve the needs of IDDRC investigators.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD071593-04
Application #
8734922
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2014
Total Cost
$123,888
Indirect Cost
$49,703
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Saied-Santiago, Kristian; Bülow, Hannes E (2018) Diverse roles for glycosaminoglycans in neural patterning. Dev Dyn 247:54-74
Wang, Ping; Zhao, Dejian; Lachman, Herbert M et al. (2018) Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons. Transl Psychiatry 8:13
Zhao, Yingjie; Guo, Tingwei; Fiksinski, Ania et al. (2018) Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects. Am J Med Genet A 176:2172-2181
Boudewyn, Lauren C; Walkley, Steven U (2018) Current concepts in the neuropathogenesis of mucolipidosis type IV. J Neurochem :
Wilson, Tommy J; Gray, Michael J; Van Klinken, Jan-Willem et al. (2018) Macronutrient composition of a morning meal and the maintenance of attention throughout the morning. Nutr Neurosci 21:729-743
Barnes, Jesse; Salas, Franklin; Mokhtari, Ryan et al. (2018) Modeling the neuropsychiatric manifestations of Lowe syndrome using induced pluripotent stem cells: defective F-actin polymerization and WAVE-1 expression in neuronal cells. Mol Autism 9:44
Celestrin, Kevin; Díaz-Balzac, Carlos A; Tang, Leo T H et al. (2018) Four specific immunoglobulin domains in UNC-52/Perlecan function with NID-1/Nidogen during dendrite morphogenesis in Caenorhabditis elegans. Development 145:
Thomsen, Anna M; Gulinello, Maria E; Wen, Jing et al. (2018) Liposomal Cytarabine Induces Less Neurocognitive Dysfunction Than Intrathecal Methotrexate in an Animal Model. J Pediatr Hematol Oncol 40:e91-e96
Pera, Marta; Larrea, Delfina; Guardia-Laguarta, Cristina et al. (2017) Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. EMBO J 36:3356-3371
Boudewyn, Lauren C; Sikora, Jakub; Kuchar, Ladislav et al. (2017) N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV. Neurobiol Dis 105:257-270

Showing the most recent 10 out of 128 publications