We are in the midst of a revolution regarding our evolving understanding of the molecular mechanisms underlying normal embryogenesis and neural development, gene-environmental interactions, associated genetic and epigenetic processes and the pathogenesis, classification and treatment of intellectual and developmental disorders (IDDs). The Tissue Engineering and Cellular Reprogramming Core (TECR) has evolved from a traditional Tissue Culture Core in our previous Kennedy Center grant to now providing an extensive, innovative, interdisciplinary, state-of-the-art array of user services to further accelerate the explosive growth in basic, translational and clinical neuroscience knowledge and scientific applications undertaken by Center investigators as a key component of the new Einstein IDDRC application. The broad scientific and technical expertise of our faculty, staff and specialized consultants and the availability of support services (Table F1) ensure that particularly novel and cross-disciplinary investigations can be fostered and adapted to the increasingly sophisticated needs of IDDRC investigators. These services are designed to facilitate research projects employing a wide variety of experimental approaches ranging from the utilization of cellular and molecular biology techniques, genomic, epigenomic and systems biological analyses and neurophysiological approaches to the study of distinct animal and human cellular and tissue preparations. The Core supplies these services in conjunction with other IDDRC Core Facilities and specialized support services by providing extensive training, oversight, facilities and novel and unique resources to expedite these interdisciplinary goals.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD071593-04
Application #
8734925
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2014
Total Cost
$127,963
Indirect Cost
$51,338
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Boudewyn, Lauren C; Sikora, Jakub; Kuchar, Ladislav et al. (2017) N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV. Neurobiol Dis 105:257-270
Pera, Marta; Larrea, Delfina; Guardia-Laguarta, Cristina et al. (2017) Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. EMBO J 36:3356-3371
Melentijevic, Ilija; Toth, Marton L; Arnold, Meghan L et al. (2017) C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature 542:367-371
Kikusui, Takefumi; Hiroi, Noboru (2017) A Self-Generated Environmental Factor as a Potential Contributor to Atypical Early Social Communication in Autism. Neuropsychopharmacology 42:378
Saied-Santiago, Kristian; Townley, Robert A; Attonito, John D et al. (2017) Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans. Genetics 206:1951-1967
Ray, Alex K; DuBois, Juwen C; Gruber, Ross C et al. (2017) Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure. Glia 65:2051-2069
Zheng, Chaogu; Diaz-Cuadros, Margarete; Nguyen, Ken C Q et al. (2017) Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. Mol Biol Cell 28:2786-2801
Wang, Ping; Mokhtari, Ryan; Pedrosa, Erika et al. (2017) CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells. Mol Autism 8:11
Thomsen, Anna M; Gulinello, Maria E; Wen, Jing et al. (2017) Liposomal Cytarabine Induces Less Neurocognitive Dysfunction Than Intrathecal Methotrexate in an Animal Model. J Pediatr Hematol Oncol :
Sikora, Jakub; Dworski, Shaalee; Jones, E Ellen et al. (2017) Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. Am J Pathol 187:864-883

Showing the most recent 10 out of 119 publications