The primary aim of the Executive Team and Coordinating Core is to ensure integrated, coherent, and effective scientific operations at the HNRC. The Executive Team (ET). is comprised of the Center Director, Co-Director, Associate Directors, and Center Manager. The ET provides day-to-day leadership of the HNRC. The ET receives advice and feedback from the Scientific Advisory Board (annual independent evaluation of HNRC scientific and programmatic progress), the Participant Advisory Board (feedback from participants to the Director), and the Community Advisory Board (feedback from community providers), as well as internally from the Council of Investigators (sets policy and reviews scientific progress). The Coordinating Core implements the priorities set by the ET and provides services essential to a multiproject Center. The CC is comprised of four Units: The Administrative Unit organizes the distribution of center resources, coordinates various Center activities, organizes annual evaluations of the Center and Cores, facilitates information dissemination to the scientific and general communities, and ensures that HNRC activities are fully compliant with all university, state, and federal policies. The Data Management and Information Systems Unit (DMIS) processes all Center-related data and ensures seamless interaction with external projects via an Internet-accessible data resource system, supports international efforts, and maintains the web site for internal and external information dissemination. The Statistics Unit provides statistical services during all phases of project development, implementation, and publication of findings. The Participant Accrual and Retention (PAR) Unit recruits new cohorts of interest (e.g., early infection cases, older HIV+ adults), maintains an informative longitudinal cohort, manages a roster of potential study participants (recruiting them as required for specific studies), and provides consulting services. The DMIS, Statistics, and PAR Units also engage in methods development. Several working groups assist and guide the Core, including the Research Review Committee (reviews requests for Center resources and provides a forum to discuss proposed studies/manuscripts);the Human Subjects Committee (monitors Human Subjects and IRB issues, especially confidentiality). Through these processes and structures, the ET and Coordinating Core assure the operation of a truly multidisciplinary research center and provide central coordination and leadership for international research and training efforts.

Public Health Relevance

The ET and Coordinating Core provide scientific leadership as well as organizational infrastructure, capacity to recruit and retain study participants, statistical expertise, and data management capabilities that enable the HNRC to meet its mission of supporting state-of-the-art neuroAIDS research at the local, national and international levels.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Heaton, Robert K; Franklin Jr, Donald R; Deutsch, Reena et al. (2015) Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis 60:473-80
Hobkirk, Andréa L; Starosta, Amy J; De Leo, Joseph A et al. (2015) Psychometric validation of the BDI-II among HIV-positive CHARTER study participants. Psychol Assess 27:457-66
Morgan, Erin E; Iudicello, Jennifer E; Cattie, Jordan E et al. (2015) Neurocognitive impairment is associated with lower health literacy among persons living with HIV infection. AIDS Behav 19:166-77
Casaletto, K B; Obermeit, L; Morgan, E E et al. (2015) Depression and executive dysfunction contribute to a metamemory deficit among individuals with methamphetamine use disorders. Addict Behav 40:45-50
Repunte-Canonigo, Vez; Lefebvre, Celine; George, Olivier et al. (2014) Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Mol Neurodegener 9:26
Fazeli, Pariya L; Woods, Steven Paul; Heaton, Robert K et al. (2014) An active lifestyle is associated with better neurocognitive functioning in adults living with HIV infection. J Neurovirol 20:233-42
Andrade, Rosa M; Torriani, Francesca J; Ellis, Ronald J (2014) Acute HIV infection presenting as fulminant meningoencephalitis with massive CSF viral replication. Neurol Clin Pract 4:256-259
Orlov, Marika; Vaida, Florin; Williamson, Kathryn et al. (2014) Antigen-presenting phagocytic cells ingest malaria parasites and increase HIV replication in a tumor necrosis factor ?-dependent manner. J Infect Dis 210:1562-72
Overk, Cassia R; Masliah, Eliezer (2014) Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol 88:508-16
Akolo, Christopher; Royal 3rd, Walter; Cherner, Mariana et al. (2014) Neurocognitive impairment associated with predominantly early stage HIV infection in Abuja, Nigeria. J Neurovirol 20:380-7

Showing the most recent 10 out of 313 publications