The prevalence of mental health illness among patients with HIV is a significant public health issue. The translation of discoveries found at the bench to clinical practice (bench to bedside) is critical for advancements in diagnosing and therapeutic intervention to be made. This relationship, however, is not a one-way street, but bi-directional, where observations made in a clinical setting may also stimulate research at the bench. As such, it is important to develop a collaborative, multi-disciplinary community of clinicians and scientists to foster new discoveries with practical application in diagnosing and treating HIV+ persons with neuropsychological illness. To address this need, the Clinical and Behavioral Core will assist basic and clinical investigators wishing to include human subjects from a well-characterized cohort of HIV+ individuals in their studies, including those assessed for neuropsychological function. We will assist new and established investigators in the design and coordination of their studies, the preparation of required forms and approvals and data collection. To achieve this, the Clinical and Behavioral Core will have three primary functions: 1.) Provide the clinical cohort from the Temple Comprehensive HIV program with its infrastructure, operations management and regulatory oversight for clinical studies involving other CNACC cores or non-CNACC clinical collaborators, 2.) Systematically collect baseline and longitudinal neurocognitive, neurologic and psychiatric assessments on patients in Temple's HIV practice in collaboration with the Department of Psychiatry (for our revised application, we have included an expert neuropsychologist with HIV/AIDS neurocognitive testing and analysis experience, recently hired by Temple University Hospital (Dr. Nancy Minniti) and a consultant with internationally recognized expertise in neurocognitive testing, Dr. Kevin Robertson from the University of North Carolina.), and 3.) Develop and maintain a neurodatabase that will contain data from assessments in function #2, as well as relevant immunologic and virologic data from the Temple HIV clinical database and other studies conducted through CNACC.

Public Health Relevance

This core enables the integration of basic science investigations with clinical populations to further the aims of neuroscience translational research and expand opportunities for cross-disciplinary studies in epidemiology, public health and behavioral medicine. The core research activities foster the evaluation and application of novel targets and therapies in the management and care of HIV infected patients.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Temple University
United States
Zip Code
Antell, Gregory C; Dampier, Will; Aiamkitsumrit, Benjamas et al. (2017) Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences. Int J Genomics 2017:4081585
Dampier, Will; Antell, Gregory C; Aiamkitsumrit, Benjamas et al. (2017) Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status. J Neurovirol 23:113-124
Sariyer, Rahsan; De-Simone, Francesca I; Donadoni, Martina et al. (2017) Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity. Alcohol Clin Exp Res 41:1715-1724
Tahrir, Farzaneh G; Knezevic, Tijana; Gupta, Manish K et al. (2017) Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes. J Cell Physiol 232:797-805
Dampier, Will; Sullivan, Neil T; Chung, Cheng-Han et al. (2017) Designing broad-spectrum anti-HIV-1 gRNAs to target patient-derived variants. Sci Rep 7:14413
Sami Saribas, A; Cicalese, Stephanie; Ahooyi, Taha Mohseni et al. (2017) HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity. Cell Death Dis 8:e2542
Gupta, Manish K; Kaminski, Rafal; Mullen, Brian et al. (2017) HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy. Sci Rep 7:8572
Ahooyi, Taha Mohseni; Shekarabi, Masoud; Decoppet, Emilie A et al. (2017) Network Analysis of Hippocampal Neurons by Microelectrode Array in the Presence of HIV-1 Tat and Cocaine. J Cell Physiol :
O'Connor, E E; Jaillard, A; Renard, F et al. (2017) Reliability of White Matter Microstructural Changes in HIV Infection: Meta-Analysis and Confirmation. AJNR Am J Neuroradiol 38:1510-1519
Gannon, Patrick J; Akay-Espinoza, Cagla; Yee, Alan C et al. (2017) HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ?-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol 187:91-109

Showing the most recent 10 out of 115 publications