This Core has two related components that offer different services. The CNS/PNS Injury Core will provide technical support to generate animal models of Injury and to characterize their behavioral impairment after injury. The Rodent Behavior Core will provide services to test rodent models in standard behavioral paradigms. This Core component also synergizes with the Genetics Core and provides a mechanism to analyze the behavior of transgenic and knockout mice. I. CNS/PSN Nerve Injury Core Overview The study of CNS/PNS nerve Injury is a major strength on the OSU campus. With the services available in this Core, NINDS funded investigators will be able to greatly expand the scope of their work by having easy access to an array of surgical and behavioral techniques which are not typically located together in a single laboratory. This Core will also provide the ability to test novel agents in CNS/PNS Injury models. During the current award nine Pis used this Core resulting in sixteen papers and one new R01.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Ohio State University
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Banasavadi-Siddegowda, Y K; Russell, L; Frair, E et al. (2017) PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. Oncogene 36:263-274
Goldstein, Evan Z; Church, Jamie S; Pukos, Nicole et al. (2017) Intraspinal TLR4 activation promotes iron storage but does not protect neurons or oligodendrocytes from progressive iron-mediated damage. Exp Neurol 298:42-56
Church, Jamie S; Milich, Lindsay M; Lerch, Jessica K et al. (2017) E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord. Glia 65:883-899
Pan, Christopher C; Shah, Nirav; Kumar, Sanjay et al. (2017) Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy. Oncotarget 8:12675-12685
Duy, Phan Q; Berberoglu, Michael A; Beattie, Christine E et al. (2017) Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. Neuroscience 349:118-127
Siu, J J; Queen, N J; Huang, W et al. (2017) Improved gene delivery to adult mouse spinal cord through the use of engineered hybrid adeno-associated viral serotypes. Gene Ther 24:361-369
Weil, Zachary M; Karelina, Kate (2017) Traumatic Brain Injuries during Development: Implications for Alcohol Abuse. Front Behav Neurosci 11:135
Saad, Nancy S; Repas, Steven J; Floyd, Kyle et al. (2017) Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice. Biomed Res Int 2017:6071031
Welker, Alessandra M; Jaros, Brian D; An, Min et al. (2017) Changes in tumor cell heterogeneity after chemotherapy treatment in a xenograft model of glioblastoma. Neuroscience 356:35-43
Chang, Yi Seok; Jalgaonkar, Swati P; Middleton, Justin D et al. (2017) Stress-inducible gene Atf3 in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis. Proc Natl Acad Sci U S A 114:E7159-E7168

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