Abstract

Core C (Vector) will consult with and advise investigators on vector design and applications in the nervous system, and provide high titer, high quality lentivirus, retrovirus, replication-deficient rabies virus and AAV vectors to monitor gene delivery and neural functions in culture and in rodent models of neurologic disorders. This core will also provide specialized expertise and technologies to our investigators to achieve widespread and targeted gene delivery in the nervous system in utero, neonatal, and adult mice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS045776-11A1
Application #
8731688
Study Section
Special Emphasis Panel (ZNS1-SRB-B (38))
Project Start
Project End
Budget Start
2015-01-15
Budget End
2015-11-30
Support Year
11
Fiscal Year
2015
Total Cost
$217,474
Indirect Cost
$92,489

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Pagnier, Guillaume J; Kastanenka, Ksenia V; Sohn, Miwon et al. (2018) Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models. Alzheimers Res Ther 10:11
Jorfi, Mehdi; D'Avanzo, Carla; Kim, Doo Yeon et al. (2018) Three-Dimensional Models of the Human Brain Development and Diseases. Adv Healthc Mater 7:
Landeira, Bruna Soares; Santana, Themis Taynah da Silva; Araújo, Jéssica Alves de Medeiros et al. (2018) Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development. Cereb Cortex 28:538-548
György, Bence; Cruz, Lilian; Yellen, David et al. (2018) Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts. Sci Rep 8:2324
DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin et al. (2018) Tau reduction in the presence of amyloid-? prevents tau pathology and neuronal death in vivo. Brain 141:2194-2212
Teng, Jian; Hejazi, Seyedali; Hiddingh, Lotte et al. (2018) Recycling drug screen repurposes hydroxyurea as a sensitizer of glioblastomas to temozolomide targeting de novo DNA synthesis, irrespective of molecular subtype. Neuro Oncol 20:642-654
Kovalenko, Marina; Milnerwood, Austen; Giordano, James et al. (2018) HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction. J Huntingtons Dis 7:17-33
Jorfi, Mehdi; D'Avanzo, Carla; Tanzi, Rudolph E et al. (2018) Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Sci Rep 8:2450
György, Bence; Sage, Cyrille; Indzhykulian, Artur A et al. (2017) Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV. Mol Ther 25:379-391
Maesako, Masato; Horlacher, Jana; Zoltowska, Katarzyna M et al. (2017) Pathogenic PS1 phosphorylation at Ser367. Elife 6:

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