&

Public Health Relevance

Recent establishment of the NIH-supported small-molecule screening centers provide an unprecedented opportunity for researchers at academic institutions to identify tool compounds and new therapeutics for diseases. Unfortunately, most neuroscientists lack the expertise and equipment needed to optimize and validate biological assays for high throughput screening (HTS), thus making it extremely difficult for neuroscientists to move their science in a translational direction. The main objective of the Translational Neuroscience Core (formerly called Assay Development Core) is to develop? and validate high-throughput compatible assays that could facilitate discovery of new treatments for neurological diseases. Indeed, the key function of this Core is to enable individual investigators to utilize the small molecule library screening facilities available at. UNC and at NIH-funded facilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS045892-11
Application #
8791164
Study Section
Special Emphasis Panel (ZNS1-SRB-R (59))
Project Start
Project End
Budget Start
2014-02-01
Budget End
2014-11-30
Support Year
11
Fiscal Year
2014
Total Cost
$69,736
Indirect Cost
$23,857
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Burette, Alain C; Park, Haram; Weinberg, Richard J (2014) Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons. J Comp Neurol 522:2164-78
Wright, Brittany D; Loo, Lipin; Street, Sarah E et al. (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82:836-47
Huang, Hsien-Sung; Yoon, Bong-June; Brooks, Sherian et al. (2014) Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice. PLoS One 9:e98383
Mabb, Angela M; Kullmann, Paul H M; Twomey, Margaret A et al. (2014) Topoisomerase 1 inhibition reversibly impairs synaptic function. Proc Natl Acad Sci U S A 111:17290-5
Zhu, Hu; Pleil, Kristen E; Urban, Daniel J et al. (2014) Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory. Neuropsychopharmacology 39:1880-92
Demyanenko, Galina P; Mohan, Vishwa; Zhang, Xuying et al. (2014) Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling. J Neurosci 34:11274-87
Larsen, Rylan S; Smith, Ikuko T; Miriyala, Jayalakshmi et al. (2014) Synapse-specific control of experience-dependent plasticity by presynaptic NMDA receptors. Neuron 83:879-93
McNeill, Robert S; Schmid, Ralf S; Bash, Ryan E et al. (2014) Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice. J Vis Exp :
Gama, Vivian; Swahari, Vijay; Schafer, Johanna et al. (2014) The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells. Sci Signal 7:ra67
Morgan-Smith, Meghan; Wu, Yaohong; Zhu, Xiaoqin et al. (2014) GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation. Elife 3:e02663

Showing the most recent 10 out of 54 publications