Affymetrix gene expression system of the Computational Genomics Core during the next funding period. D2. Electrophysiology &Biophysics Core Facility (EBCF) D2.1. Rationale and Mission. Electrophysiological data are often considered the gold standard for demonstrating a causal relationship between ion flux and cell physiology. Generating preliminary data is a daunting prospect, however, for an investigator who lacks the years of training necessary to produce a competent, independent electrophysiologist. Electrophysiological studies also require a considerable up-front investment in personnel and equipment, further discouraging investigators from entering the electrophysiological arena. The EBCF was established to counterbalance these negative influences and lower the activation energy barrier sufficiently so as to promote more widespread use of electrophysiological approaches in neuroscience research laboratories at Tufts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS047243-10
Application #
8441554
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
10
Fiscal Year
2013
Total Cost
$146,476
Indirect Cost
$57,703
Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Drane, Laurel; Ainsley, Joshua A; Mayford, Mark R et al. (2014) A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system. Front Mol Neurosci 7:82
Darcy, Michael J; Trouche, St├ęphanie; Jin, Shan-Xue et al. (2014) Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus. Hippocampus 24:1317-29
Lee, Vallent; Sarkar, Jhimly; Maguire, Jamie (2014) Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology 41:75-88
Ainsley, Joshua A; Drane, Laurel; Jacobs, Jonathan et al. (2014) Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience. Nat Commun 5:4510
Brinsmade, Shaun R; Alexander, Elizabeth L; Livny, Jonathan et al. (2014) Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY. Proc Natl Acad Sci U S A 111:8227-32
Darcy, Michael J; Trouche, Stephanie; Jin, Shan-Xue et al. (2014) Age-dependent role for Ras-GRF1 in the late stages of adult neurogenesis in the dentate gyrus. Hippocampus 24:315-25
Jin, Shan-Xue; Bartolome, Christopher; Arai, Junko A et al. (2014) Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2. J Biol Chem 289:16551-64
Dahlberg, Caroline L; Juo, Peter (2014) The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans. J Biol Chem 289:3444-56
O'Toole, Kate K; Hooper, Andrew; Wakefield, Seth et al. (2014) Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res 108:29-43
Scholl, Elizabeth Storer; Pirone, Antonella; Cox, Daniel H et al. (2014) Alternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levels. Channels (Austin) 8:62-75

Showing the most recent 10 out of 105 publications