and Relevance. Studies of animal behavior are necessary to characterize cardinal symptoms of disorders for which altered genetic expression and neurochemistry have been proposed. Comprehensive behavioral phenotyping, however, requires expertise and instrumentation beyond the financial and technical capabilities of most individual investigators. The mission of the ABC is to provide access to a state of the art behavioral assessment facility and expert services for assessing the behavioral effects of neuropharmacological or molecular genetic manipulations in order to identify therapeutic targets for treating CNS disorders. Since its inception in 2004, the ABC has served over 38 investigators within the neuroscience community? The ABC is a high impact resource;experiments accomplished using the ABC and its services have resulted in 13 publications and 29 NIH? funded grants. The ABC is emerging as a regional resource, serving neuroscientists within the Tufts community and drawing investigators from neighboring institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS047243-11
Application #
8787524
Study Section
Special Emphasis Panel (ZNS1-SRB-R (59))
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
11
Fiscal Year
2014
Total Cost
$128,783
Indirect Cost
$50,733
Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Drane, Laurel; Ainsley, Joshua A; Mayford, Mark R et al. (2014) A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system. Front Mol Neurosci 7:82
Darcy, Michael J; Trouche, St├ęphanie; Jin, Shan-Xue et al. (2014) Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus. Hippocampus 24:1317-29
Lee, Vallent; Sarkar, Jhimly; Maguire, Jamie (2014) Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology 41:75-88
Ainsley, Joshua A; Drane, Laurel; Jacobs, Jonathan et al. (2014) Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience. Nat Commun 5:4510
Brinsmade, Shaun R; Alexander, Elizabeth L; Livny, Jonathan et al. (2014) Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY. Proc Natl Acad Sci U S A 111:8227-32
Darcy, Michael J; Trouche, Stephanie; Jin, Shan-Xue et al. (2014) Age-dependent role for Ras-GRF1 in the late stages of adult neurogenesis in the dentate gyrus. Hippocampus 24:315-25
Jin, Shan-Xue; Bartolome, Christopher; Arai, Junko A et al. (2014) Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2. J Biol Chem 289:16551-64
Dahlberg, Caroline L; Juo, Peter (2014) The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans. J Biol Chem 289:3444-56
O'Toole, Kate K; Hooper, Andrew; Wakefield, Seth et al. (2014) Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res 108:29-43
Scholl, Elizabeth Storer; Pirone, Antonella; Cox, Daniel H et al. (2014) Alternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levels. Channels (Austin) 8:62-75

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