and Relevance. Studies of animal behavior are necessary to characterize cardinal symptoms of disorders for which altered genetic expression and neurochemistry have been proposed. Comprehensive behavioral phenotyping, however, requires expertise and instrumentation beyond the financial and technical capabilities of most individual investigators. The mission of the ABC is to provide access to a state of the art behavioral assessment facility and expert services for assessing the behavioral effects of neuropharmacological or molecular genetic manipulations in order to identify therapeutic targets for treating CNS disorders. Since its inception in 2004, the ABC has served over 38 investigators within the neuroscience community? The ABC is a high impact resource;experiments accomplished using the ABC and its services have resulted in 13 publications and 29 NIH? funded grants. The ABC is emerging as a regional resource, serving neuroscientists within the Tufts community and drawing investigators from neighboring institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS047243-11
Application #
8787524
Study Section
Special Emphasis Panel (ZNS1-SRB-R (59))
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
11
Fiscal Year
2014
Total Cost
$128,783
Indirect Cost
$50,733
Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Park, Kellie A; Ribic, Adema; Laage Gaupp, Fabian M et al. (2016) Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. J Neurosci 36:7464-75
Chen, Wei-Sheng; Cao, Zhiyi; Sugaya, Satoshi et al. (2016) Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun 7:11302
Cárdenas, César; Müller, Marioly; McNeal, Andrew et al. (2016) Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria. Cell Rep 14:2313-24
Armbruster, Moritz; Hanson, Elizabeth; Dulla, Chris G (2016) Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. J Neurosci 36:10404-10415
Hanson, Elizabeth; Danbolt, Niels Christian; Dulla, Chris G (2016) Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiol Dis 89:157-68
Walker, Kendall R; Modgil, Amit; Albrecht, David et al. (2016) Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission. PLoS One 11:e0155799
Yeates, Eniola Funmilayo Aduke; Tesco, Giuseppina (2016) The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation. J Biol Chem 291:15753-66
Zhao, Jin; Schnitzler, Gavin R; Iyer, Lakshmanan K et al. (2016) MicroRNA-Offset RNA Alters Gene Expression and Cell Proliferation. PLoS One 11:e0156772
Hooper, Andrew; Maguire, Jamie (2016) Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus 26:41-53
Lee, Vallent; MacKenzie, Georgina; Hooper, Andrew et al. (2016) Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus 26:1276-90

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