This is a competitive renewal application from a successful University of Alabama at Birmingham (UAB) Neuroscience Core Center. The Neuroscience Core Center at UAB builds upon the University's 30 years of contributions to interdisciplinary neuroscience research. The mission of the Core Center is to provide stateof- the-art resources that advance collaborative team approaches to neuroscience. The Behavioral Assessment Core (Core A) provides both service-oriented behavioral phenotyping and research staff training to investigators using rodents. In the renewal, facilities for emotional and fear conditioning, an important emerging area of research within the UAB Neuroscience community, will be added. The Molecular Detection Core (Core B) will offer sensitive, standardized immunohistochemistry and in situ hybridization technologies. The utility of this core will be enhanced by the addition of facilities for tissue sectioning and embedding. An increased focus on protocol development and investigator training will insure that these methods are successfully transferred to individual groups of investigators. The Protein Interaction Core (Core C) services will provide expression cloning of cDNAs and genomic sequences in vectors appropriate for identification of protein interactions, perform two-hybrid screening to identify protein interactions and provide viral vectors for expression of GFP and/or shRNA. New tervices will include constructs for tandem affinity pruification (TAP) and adenoviruses (AAVs) for in vivo applications. Core C will emphasize generation of vectors and viruses that can be used in vivo. The Administrative Core (Core D) will provide administrative and scientific leadership. In the renewal, Core D leadership will also provide active mentorship of junior faculty in Co- Director positions. Collectively, the cores promote multidisciplinary collaboration and exchange of information and technologic advances, attract new investigators to neuroscience research, develop collaborative research activities with other institutions and increase the quality and productivity of funded research projects in a cost-effective manner.

Public Health Relevance

NINDS-funded UAB investigators conduct research on the causes, prevention and treatment of neurological disorders. The UAB Neuroscience Core Center provides support for these endeavors, thereby increasing the productivity of these researchers and enhancing the impact of their neuroscience research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS047466-07
Application #
8213432
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Talley, Edmund M
Project Start
2003-12-01
Project End
2015-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
7
Fiscal Year
2012
Total Cost
$711,265
Indirect Cost
$225,760
Name
University of Alabama Birmingham
Department
Neurosciences
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Qin, Hongwei; Buckley, Jessica A; Li, Xinru et al. (2016) Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration. J Neurosci 36:5144-59
Jansone, Baiba; Kadish, Inga; van Groen, Thomas et al. (2016) Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female mice. Pharmacol Res 113:781-787
Heaven, Michael R; Flint, Daniel; Randall, Shan M et al. (2016) Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease. J Proteome Res 15:2265-82
Dieni, Cristina V; Panichi, Roberto; Aimone, James B et al. (2016) Low excitatory innervation balances high intrinsic excitability of immature dentate neurons. Nat Commun 7:11313
Kadish, Inga; Kumar, Ashish; Beitnere, Ulrika et al. (2016) Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice. Exp Gerontol 86:39-49
Patel, Preeyam S; King, R Glenn; Kearney, John F (2016) Pulmonary α-1,3-Glucan-Specific IgA-Secreting B Cells Suppress the Development of Cockroach Allergy. J Immunol 197:3175-3187
Lavalley, Nicholas J; Slone, Sunny R; Ding, Huiping et al. (2016) 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. Hum Mol Genet 25:109-22
Kumar, Ashish; Zhang, Jennifer; Tallaksen-Greene, Sara et al. (2016) Allelic series of Huntington's disease knock-in mice reveals expression discorrelates. Hum Mol Genet 25:1619-36
Brady, Lillian J; Bartley, Aundrea F; Li, Qin et al. (2016) Transcriptional dysregulation causes altered modulation of inhibition by haloperidol. Neuropharmacology 111:304-313
Patterson, Kelsey C; Hawkins, Virginia E; Arps, Kara M et al. (2016) MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Hum Mol Genet 25:3303-3320

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