This Is a competitive renewal of the Rocky Mountain Neurological Disorder Center (RMNOC) whose main goal Is to enhance and further research in areas of neurobiology targeted by the NINOS. The RMNO Center Core has established facilities that allow efficient generation and use of genetically-altered animals that display Interesting and Informative functional or behavioral phenotypes. Our existing cores have all been extremely successful and evolved to enable state-of-the-art approaches thereby allowing users to perform collaborative research in an efficient manner. Therefore, we propose to maintain the original cores with their original names, emphasizing that they will continue to evolve over the next five years, as described in the application (Cores A, 6, C, and 0). As before, the services provided by the four cores are not available elsewhere at the Anschutz Medical Campus. We propose four core facilities for the RMNO Center Core: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) N design and construct vectors to generate gene-targeted and transgenic mice as well as viral targeting vectors. Core CZebrafish Transgenic Core (Angeles Ribera, Director)m provide services for maintaining and characterizing transgenic zebraflsh. Core D Machine Shop Core (Ulli Bayer, Director) will provide machine shop support services.

Public Health Relevance

The major goal of the NINOS Is to reduce the burden of neurological disease. Meeting this goal requires fostering both basic and clinical neuroscience research. The Center Core fosters NINOS goals by enabling incorporation of cutting-edge genetic, molecular and imaging approaches into research that uses powerful vertebrate model systems (mice, rat and zebrafish).

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS048154-08
Application #
8396388
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Talley, Edmund M
Project Start
2004-04-01
Project End
2015-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
8
Fiscal Year
2013
Total Cost
$698,153
Indirect Cost
$241,844
Name
University of Colorado Denver
Department
Physiology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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