Core C ? Behavioral and In Vivo Neurophysiology Core (BINC) Summary The Behavioral and In Vivo Neurophysiology Core (BINC) will provide appropriate facilities and educational and consulting services that allow Rocky Mountain Neurological Disorders Center Core (RMNDC) investigators to perform behavioral and in vivo neurophysiological phenotyping of rodent models. Behavioral phenotyping, through structured established and novel tasks, is necessary for all aspects of basic and translational neuroscience research. Behavioral testing allows detailed characterization of motor, sensory, emotional, social and cognitive output of brain circuits that can be correlated to investigator initiated manipulations. Similarly, video monitoring coupled with electroencephalography (EEG) /local field potentials (LFP) characteristics can be used to determine disease status, to understand the mechanisms of co-morbidity that can occur following an injury and to track the evolution of disease pathology after an initial insult. The ability to link findings from the subcellular level (e.g. Core B) to the output of brain circuits (e.g. Core A) through behavioral and neurophysiological characterization is both exciting and highly relevant to the mission of NINDS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS048154-13
Application #
9402666
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
13
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Sinnen, Brooke L; Bowen, Aaron B; Forte, Jeffrey S et al. (2017) Optogenetic Control of Synaptic Composition and Function. Neuron 93:646-660.e5
Soltys, John N; Meyer, Stephanie A; Schumann, Hannah et al. (2017) Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy. Biophys J 112:1692-1702
Goodell, Dayton J; Zaegel, Vincent; Coultrap, Steven J et al. (2017) DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep 19:2231-2243
Moreno, Rosa L; Josey, Megan; Ribera, Angeles B (2017) Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons. J Vis Exp :
Dittmer, Philip J; Wild, Angela R; Dell'Acqua, Mark L et al. (2017) STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep 19:321-334
Gilmer, Jesse I; Person, Abigail L (2017) Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity. J Neurosci 37:12153-12166
Westacott, Matthew J; Ludin, Nurin W F; Benninger, Richard K P (2017) Spatially Organized ?-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans. Biophys J 113:1093-1108
Lam, Philip M; Carlsen, Jessica; González, Marco I (2017) A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. Neurobiol Dis 102:1-10
McElroy, Pallavi B; Liang, Li-Ping; Day, Brian J et al. (2017) Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation. Exp Neurol 298:13-22
Westacott, Matthew J; Farnsworth, Nikki L; St Clair, Joshua R et al. (2017) Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets. Diabetes 66:2436-2445

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