In this competitive renewal of our Institutional Center Core Grant to support neuroscience research, we propose to maintain and expand the operation of three existing Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that were established during the previous funding period of this Center Grant: a Multiphoton Imaging Core, a Monoclonal Antibody Core, and an Embryonic Stem Cell Engineering Core. These facilities currently provide necessary resources and perform required services that impractical for individual laboratories to provide on their own. Use of these Core facilities will continue to greatly benefit NINDS-funded research programs of the eleven Primary Center Investigators, and also other NINDS-funded investigators at JHU SOM, by providing access to unique equipment, training in new methodologies, and development of new reagents. The experimental opportunities and technical services offered by these three Cores complement, but do not duplicate, other Core facilities available to NINDSfunded investigators at JHU SOM. Seven of the eleven Primary Center Investigators are members of the Department of Neuroscience, four are members of the Department of Neurology,a nd one is in the Department of Pathology. The research programs of the Primary Center Investigators address unresolved issues in the areas of neural and glial development, synaptic structure and function, sensory transduction, and activity-dependent regulation of gene expression.
The Specific Aims of Primary Center Investigators' NINDS-funded research programs address critical clinical issues, including the developmental origins of neurological disorders, the promotion of neuronal regeneration following injury or degeneration, the underlying basis of neuropathic pain, and the origin of neurodegenerative disorders (Alzheimer's Dementia and Amyotrophic Lateral Sclerosis). The Primary Center Investigators constitute a highly interactive group with a history of seamless collaborative research efforts. The goal of this Center is to augment existing research programs by providing these investigators, and other NINDS-funded investigators at JHU SOM, with Core facilities that are not available elsewhere at this institution.

Public Health Relevance

The relevance of this application to support the operations of JHU SOM P30 NINDS Center Cores lies in the ability of these Cores to grealty facilitate progress of NINDS-funded JHU SOM projects, providing experimental support beyond what is possible in invidivudal laboratories. These projects address clinically relevant issues related to neurological and psychiatric disorders, and neuronal de- and regeneration.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Talley, Edmund M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Schools of Medicine
United States
Zip Code
Kajstura, Tymoteusz J; Dougherty, Sarah E; Linden, David J (2017) Serotonin axons in the neocortex of the adult female mouse regrow after traumatic brain injury. J Neurosci Res :
Vyas, Pankhuri; Wu, Jingjing Sherry; Zimmerman, Amanda et al. (2017) Tyrosine Hydroxylase Expression in Type II Cochlear Afferents in Mice. J Assoc Res Otolaryngol 18:139-151
Agarwal, Amit; Wu, Pei-Hsun; Hughes, Ethan G et al. (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93:587-605.e7
Xie, Xiaojun; Tabuchi, Masashi; Brown, Matthew P et al. (2017) The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections. Elife 6:
Cave, Clinton; Park, Sungjin; Rodriguez, Marianeli et al. (2017) GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Mol Neurodegener 12:8
Severson, Kyle S; Xu, Duo; Van de Loo, Margaret et al. (2017) Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents. Neuron 94:666-676.e9
Wang, Qiang; Chiu, Shu-Ling; Koropouli, Eleftheria et al. (2017) Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron 96:1084-1098.e7
Shevelkin, Alexey V; Terrillion, Chantelle E; Abazyan, Bagrat N et al. (2017) Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice. Neurobiol Dis 103:144-153
Chen, Chih-Ming; Orefice, Lauren L; Chiu, Shu-Ling et al. (2017) Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proc Natl Acad Sci U S A 114:E619-E628
Kim, Juhyun; Hughes, Ethan G; Shetty, Ashwin S et al. (2017) Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci 37:9037-9053

Showing the most recent 10 out of 68 publications