Applications of magnetic resonance (MR) techniques to research in the life sciences are growing rapidly. State-of-the-art heteronuclear MR spectroscopy (MRS) and multi-modal MR imaging (MRI) methodologies cultivated at the Magnetic Resonance Research Center (MRRC) at Yale have moved in vivo animal research into central roles in experimental neuroscience, addressing fundamental issues with far reaching implications for brain function. Since the formation of the Yale MRRC in the early in 1980s, the number of horizontal-bore magnets for in vivo studies has multiplied three-fold in 2004. The present number of magnets for in vivo studies - three each for animals and humans - were needed to match the growing number of investigators across many disciplines - a majority of whom are supported by NINDS. The strength of the Yale MRRC has been, and still is, the dynamic interaction between rodent and human research. Active interplay between heteronuclear MRS and multi-modal MRI methods in rodents and humans have furthermore rapidly progressed. Because MR technology requires unwavering infrastructural support for state-of-the-art exploits to be successfully applied, long-term stability of Yale MRRC is contingent on sustained support. A program in """"""""Quantitative Neuroscience with Magnetic Resonance (QNMR)"""""""" at Yale will support shared resources and facilities used by NINDS-funded investigators at Yale, and thereby generate greater productivity than would be possible via independent efforts. QNMR will consist of three research Cores - each dedicated to improving effectiveness of ongoing research based upon multi- modal MRI, heteronuclear MRS, neurophysiology - and one service Core - designed for rapid data analysis, access, sharing, and backup using high-performance cluster of workstations. We expect that QNMR will promote a more cooperative and interactive research environment for neuroscientists who are utilizing MR technology at Yale, and will nurture new cross-disciplinary approaches in medicine, physiology, and neuroscience.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS052519-05
Application #
8046306
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Talley, Edmund M
Project Start
2007-06-01
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2013-11-30
Support Year
5
Fiscal Year
2012
Total Cost
$777,297
Indirect Cost
$307,631
Name
Yale University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Shu, Christina Y; Herman, Peter; Coman, Daniel et al. (2016) Brain region and activity-dependent properties of M for calibrated fMRI. Neuroimage 125:848-56
Zhan, Qiong; Buchanan, Gordon F; Motelow, Joshua E et al. (2016) Impaired Serotonergic Brainstem Function during and after Seizures. J Neurosci 36:2711-22
Park, Kellie A; Ribic, Adema; Laage Gaupp, Fabian M et al. (2016) Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. J Neurosci 36:7464-75
Hsieh, Lawrence S; Wen, John H; Claycomb, Kumiko et al. (2016) Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Nat Commun 7:11753
Coman, Daniel; Huang, Yuegao; Rao, Jyotsna U et al. (2016) Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas. NMR Biomed 29:309-19
Kaneko, Gen; Sanganahalli, Basavaraju G; Groman, Stephanie M et al. (2016) Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biol Psychiatry :
Pirazzoli, Valentina; Ayeni, Deborah; Meador, Catherine B et al. (2016) Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma. Clin Cancer Res 22:426-35
Shu, Christina Y; Sanganahalli, Basavaraju G; Coman, Daniel et al. (2016) Quantitative β mapping for calibrated fMRI. Neuroimage 126:219-28
Juchem, Christoph; de Graaf, Robin A (2016) The public multi-coil information (PUMCIN) policy. Magn Reson Med :
Hyder, Fahmeed; Herman, Peter; Bailey, Christopher J et al. (2016) Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis. J Cereb Blood Flow Metab 36:903-16

Showing the most recent 10 out of 124 publications