For the past four years, the Neuropathology Core at the Neurosciences and Pathology Departments at UCSD has been operating under the auspices of the NIH Blueprint Neurosciences Core Grant (Stuart Lipton, PI), and is primarily focused at better understanding the mechanisms of synaptic pathology and at developing new experimental therapies for Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Neurodevelopmental abnormalities, HIV associated dementia (HAD), and other neurodegenerative conditions. This Core Laboratory is headed by Dr. Eliezer Masliah, who has collaborated with a number of neuroscientists on the La Jolla Torrey Pines Mesa and elsewhere for many years, but these facilities had not been previously available to all neuroscientists as a Core until the NIH Blueprint Neuroscience Core Grant was funded. Since the Blueprint Core Grant program is being discontinued by NIH, this NINDS P30 core funding is now requested to continue this core for La Jolla Neuroscientists who are NINDS investigators. Dr. Masliah will continue serve as Director of the Neuropathology Core, which will continue to be located at UCSD. This Core will foster further collaborations and enhance research into neurodegenerative disorders in the San Diego area by NINDS scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS076411-02
Application #
8382287
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
2
Fiscal Year
2012
Total Cost
$193,182
Indirect Cost
$568
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Satoh, Takumi; Lipton, Stuart (2017) Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate. F1000Res 6:2138
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