Drosophila is one of the outstanding models for studies of animal genetics, development, and regulation. As a genetic model, it has been characterized more fully than any other metazoan. At the same time, because of evolutionary conservation, Drosophila has turned out to be an important model for fundamental studies of medical, agricultural, and biotechnological interest. Thus, it appears that >75 percent of human disease genes have Drosophila homologs. The completed Drosophila genome sequence, ongoing EST projects, and the increasing application of high-throughput genomics techniques by fly workers are paving the way for a comprehensive functional genomics of Drosophila. To reach this goal, the community requires ready, economical access to quality-assured genomics materials. The Drosophila Genomics Resource Center (DGRC) provides the research community with access to genomics resources and facilitates their effective use. Specifically, the DGRC: 1. Ensures the research community broad access to genomics resources by acquiring, archiving, curating, and distributing genomics resources including, clones, vectors, cell lines, and microarrays. 2. Facilitates the effective use of genomics resources by the research community by providing web based descriptive documentation, protocols, and guidelines;email and telephone help desk;outreach at conferences;and workshops. 3. Improves the genomics resources and protocols available to the research community.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
8P40OD010949-09
Application #
8238284
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
O'Neill, Raymond R
Project Start
2002-04-01
Project End
2013-09-02
Budget Start
2012-04-01
Budget End
2013-09-02
Support Year
9
Fiscal Year
2012
Total Cost
$756,364
Indirect Cost
$255,461
Name
Indiana University Bloomington
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Boisclair Lachance, Jean-François; Webber, Jemma L; Hong, Lu et al. (2018) Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev 32:389-401
Course, Meredith M; Scott, Anna I; Schoor, Carmen et al. (2018) Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism. Mol Biol Cell 29:1219-1227
Neuman, Sarah D; Bashirullah, Arash (2018) Hobbit regulates intracellular trafficking to drive insulin-dependent growth during Drosophila development. Development 145:
Brown, Haley E; Reichert, Marie C; Evans, Timothy A (2018) In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats. G3 (Bethesda) 8:621-630
Spinner, Michael A; Walla, David A; Herman, Tory G (2018) Drosophila Syd-1 Has RhoGAP Activity That Is Required for Presynaptic Clustering of Bruchpilot/ELKS but Not Neurexin-1. Genetics 208:705-716
Martin, Judy Lisette; Sanders, Erin Nicole; Moreno-Roman, Paola et al. (2018) Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss. Elife 7:
Okamoto, Naoki; Viswanatha, Raghuvir; Bittar, Riyan et al. (2018) A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila. Dev Cell 47:294-305.e7
Li, Hongde; Hurlburt, Alexander J; Tennessen, Jason M (2018) A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation. Dis Model Mech 11:
Caridi, Christopher P; D'Agostino, Carla; Ryu, Taehyun et al. (2018) Nuclear F-actin and myosins drive relocalization of heterochromatic breaks. Nature 559:54-60
Yue, Yang; Blasius, T Lynne; Zhang, Stephanie et al. (2018) Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. J Cell Biol 217:1319-1334

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