Zebrafish is a premiere organism to study vertebrate development, physiology, behavior, genetics and disease. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many, if not most of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish International Resource Center has been established as a repository that provides animals, materials and services to the research community. This proposal seeks continued funding 1) to provide a centralized repository for zebrafish genetic stocks and research materials, 2) to provide consultation and pathology services, and 3) to develop improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.

Public Health Relevance

The Zebrafish International Resource Genter 1) provides a centralized repository for zebrafish genetic stocks and research materials, 2) provides consultation and pathology services, and 3) develops improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
2P40OD011021-16
Application #
8552199
Study Section
Special Emphasis Panel (ZOD1)
Program Officer
Contreras, Miguel A
Project Start
1998-05-01
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Oregon
Department
Neurosciences
Type
Graduate Schools
DUNS #
City
Eugene
State
OR
Country
United States
Zip Code
97403
Samaee, Seyed-Mohammadreza; Seyedin, Sahar; Varga, Zoltan M (2017) An Affordable Intraperitoneal Injection Setup for Juvenile and Adult Zebrafish. Zebrafish 14:77-79
Varga, Zoltán M; Wilson, Carole; Alestrøm, Peter (2016) European Zebrafish Meeting 2015 Husbandry Session Report. Zebrafish 13:230-1
Yang, Huiping; Daly, Jonathan; Carmichael, Carrie et al. (2016) A Procedure-Spanning Analysis of Plasma Membrane Integrity for Assessment of Cell Viability in Sperm Cryopreservation of Zebrafish Danio rerio. Zebrafish 13:144-51
Varga, Z M; Murray, K N (2016) Health monitoring and disease prevention at the Zebrafish International Resource Center. Methods Cell Biol 135:535-51
Chow, F W; Xue, L; Kent, M L (2016) Retrospective study of the prevalence of Pseudoloma neurophilia shows male sex bias in zebrafish Danio rerio (Hamilton-Buchanan). J Fish Dis 39:367-70
Murray, Katrina N; Varga, Zoltán M; Kent, Michael L (2016) Biosecurity and Health Monitoring at the Zebrafish International Resource Center. Zebrafish 13 Suppl 1:S30-8
Varga, Z M (2016) Aquaculture, husbandry, and shipping at the Zebrafish International Resource Center. Methods Cell Biol 135:509-34
Varga, Zoltán M; Lawrence, Christian; Ekker, Stephen C et al. (2016) Universal Healthcare for Zebrafish. Zebrafish 13 Suppl 1:S1-4
Goodwin, Nicola; Karp, Natasha A; Blackledge, Samuel et al. (2016) Standardized Welfare Terms for the Zebrafish Community. Zebrafish 13 Suppl 1:S164-8
Spagnoli, Sean Thomas; Xue, Lan; Murray, Katrina N et al. (2015) Pseudoloma neurophilia: a retrospective and descriptive study of nervous system and muscle infections, with new implications for pathogenesis and behavioral phenotypes. Zebrafish 12:189-201

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