The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Santiago, the most valuable of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago (CS) in 1938.; (2) the Sabana Seca Field Station, the CPRC's head quarters located 10 miles outside of San Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology. Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects locally, national and internationally. This grant will also allow CPRC to seek additional support to develop the Translational Science Initiative (TSI) under the Applied Research Component. A major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP models for preclinical translational projects related to different human diseases. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.

Public Health Relevance

The CPRC continues to be a platform that supports numerous PHS-sponsored research projects locally, throughout USA and nationwide. The Center provides indian-origin rhesus monkeys with defined genetic and virological background that serve as models for the development of effective treatments against human diseases., The CPRC will continue to be one of the largest nation-wide provider of SPF and of conventional rhesus monkeys required for AIDS and for other biomedical research projects as well as a valuable research resource needed for behavioral and biomedical studies.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40OD012217-30
Application #
9205544
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Contreras, Miguel A
Project Start
1987-04-15
Project End
2020-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
30
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Type
University-Wide
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Weiß, Brigitte M; Kulik, Lars; Ruiz-Lambides, Angelina V et al. (2016) Individual dispersal decisions affect fitness via maternal rank effects in male rhesus macaques. Sci Rep 6:32212
Wang, Qian; Kessler, Matthew J; Kensler, Terry B et al. (2016) The mandibles of castrated male rhesus macaques (Macaca mulatta): The effects of orchidectomy on bone and teeth. Am J Phys Anthropol 159:31-51
Berman, Carol M (2016) Primate Kinship: Contributions from Cayo Santiago. Am J Primatol 78:63-77
Kulik, Lars; Langos, Doreen; Widdig, Anja (2016) Mothers Make a Difference: Mothers Develop Weaker Bonds with Immature Sons than Daughters. PLoS One 11:e0154845
Hammond, Ashley S; Johnson, Victoria P; Higham, James P (2016) Hip joint mobility in free-ranging rhesus macaques. Am J Phys Anthropol :
Hemme, Ryan R; Lopez-Ortiz, Ricardo; Garcia, Brenda Rivera et al. (2016) Serological Evidence of Infection with Endemic Human Pathogens Among Free-Ranging Old World Monkeys in Puerto Rico. Am J Trop Med Hyg 94:1095-9
Borgi, Marta; Majolo, Bonaventura (2016) Facial width-to-height ratio relates to dominance style in the genus Macaca. PeerJ 4:e1775
Kessler, Matthew J; Wang, Qian; Cerroni, Antonietta M et al. (2016) Long-term effects of castration on the skeleton of male rhesus monkeys (Macaca mulatta). Am J Primatol 78:152-66
Hernandez-Pacheco, Raisa; Delgado, Diana L; Rawlins, Richard G et al. (2016) Managing the Cayo Santiago rhesus macaque population: The role of density. Am J Primatol 78:167-81
Widdig, Anja; Langos, Doreen; Kulik, Lars (2016) Sex differences in kin bias at maturation: Male rhesus macaques prefer paternal kin prior to natal dispersal. Am J Primatol 78:78-91

Showing the most recent 10 out of 54 publications