In this renewal, the RESBIO Biomedical Technology Resource Center will build on its pioneering achievements in the development and application of advanced methods for discovery and optimization of biomaterials. The goals of the third funding period are a) expanding understanding of basic signaling mechanisms involved in cell-materials interactions, b) advancing new methods and technologies for creation of tissue scaffolds, and c) testing these advances in applications for stem cell research, tissue engineering and regenerative medicine. Six highly coordinated Technology Research and Development Projects will be conducted by a team spanning five universities and one national laboratory. In Project 1, chemists and material scientists will prepare hydrogels with ligands expressed throughout the volume and nanofiber mats with surface-tethered ligands to facilitate the study of specific biological interactions. They will also fabricate defined test beds that can be distributed among other Core projects, collaborators, and the biomedical community. In Project 2, biologists will develop composite biologic-synthetic materials that support stem cell self-renewal. Project 3 will develop approaches to enable the study of how mechanical interactions between cells and biomaterials regulate cell function and thus inform the design and fabrication of bioactive scaffolds. The Project 4 team will advance imaging-based methods to study biomaterial-driven organization of nuclear and cytoskeletal probes used to characterize stem cell intracellular signaling and organizational behaviors in 3D environments. Project 5's goal is to develop a noninvasive functional Raman imaging tool to produce 3D, chemically resolved images of live cells and tissues at microscale resolution. Project 6 will extend its multiscale computational molecular modeling approaches to guide optimization of the bioactive polymer design in Projects 1 and 2. Collaborations will challenge RESBIO's emerging technologies with projects on stem cell characterization;bone, soft tissue, and nerve regeneration;discovery of angiogenic biomaterials;and protein-polymer interactions. Well-established programs of Service, Training and Dissemination will be expanded with new content from the Core Projects, and delivered to a wider scientific community.

Public Health Relevance

RESBIO biomaterials technologies have demonstrated exceptional promise in translating state-of-the-art research findings into medical therapies that may ultimately impact millions of patients. Applications under development or already in clinical use or trials include coronary stents, ocular drug delivery therapies, and most successfully to date, anti-infective pacemaker sleeves.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
3P41EB001046-12S1
Application #
8936159
Study Section
Special Emphasis Panel (ZEB1-OSR-C (M1))
Program Officer
Hunziker, Rosemarie
Project Start
2003-04-01
Project End
2018-05-31
Budget Start
2014-09-29
Budget End
2015-05-31
Support Year
12
Fiscal Year
2014
Total Cost
$17,000
Indirect Cost
Name
Rutgers University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Singh, Sagar; Lo, Meng-Chen; Damodaran, Vinod B et al. (2016) Modeling the Insertion Mechanics of Flexible Neural Probes Coated with Sacrificial Polymers for Optimizing Probe Design. Sensors (Basel) 16:
Abramyan, Tigran M; Snyder, James A; Thyparambil, Aby A et al. (2016) Cluster analysis of molecular simulation trajectories for systems where both conformation and orientation of the sampled states are important. J Comput Chem 37:1973-82
Carlson, Aaron L; Bennett, Neal K; Francis, Nicola L et al. (2016) Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nat Commun 7:10862
Lee, Esak; Song, H-H Greco; Chen, Christopher S (2016) Biomimetic on-a-chip platforms for studying cancer metastasis. Curr Opin Chem Eng 11:20-27
Dhaliwal, Anandika; Brenner, Matthew; Wolujewicz, Paul et al. (2016) Profiling stem cell states in three-dimensional biomaterial niches using high content image informatics. Acta Biomater 45:98-109
Clements, Basak Acan; Bushman, Jared; Murthy, N Sanjeeva et al. (2016) Design of barrier coatings on kink-resistant peripheral nerve conduits. J Tissue Eng 7:2041731416629471
Bennett, Neal K; Chmielowski, Rebecca; Abdelhamid, Dalia S et al. (2016) Polymer brain-nanotherapeutics for multipronged inhibition of microglial α-synuclein aggregation, activation, and neurotoxicity. Biomaterials 111:179-189
Li, Xianfeng; Murthy, N Sanjeeva; Becker, Matthew L et al. (2016) Multiscale approach for the construction of equilibrated all-atom models of a poly(ethylene glycol)-based hydrogel. Biointerphases 11:021002
Groen, Nathalie; Guvendiren, Murat; Rabitz, Herschel et al. (2016) Stepping into the omics era: Opportunities and challenges for biomaterials science and engineering. Acta Biomater 34:133-42
Pastino, Alexandra K; Greco, Todd M; Mathias, Rommel A et al. (2016) Stimulatory effects of advanced glycation endproducts (AGEs) on fibronectin matrix assembly. Matrix Biol :

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