The daily operation and management of NESAC/BIO is the direct responsibility of its Director. Dr. David Castner. The University of Washington (UW) department and college administrations have provided autonomy to him regarding resource activities. The Associate Director. Dr. Lara Gamble, assists the Director with running the scientific components of NESAC/BIO, especially the day-to-day operations. The Associate Director also operates as the Acting Director when the Director is unavailable. The Program Manager, Ms. Mady Lund, assists the Director with running the administrative components of NESAC/BIO. The NESAC/BIO personnel include faculty (Directors plus Investigators), research staff, post-doctoral fellows, students, and administrative staff. Most of the permanent staff have been part of NESAC/BIO for many years. Thus, the procedures that have been developed for effective communication, extensive coordination of different components and tasks, and efficient operation of the resource have been well established and will be continued. NESAC/BIO faculty have active roles in the TRD, collaboration, dissemination and training components of the resource. The post-docs and students are active participants in TRD, collaboration, dissemination and training activities. The Directors and research staff are involved in all components of the NESAC/BIO scientific program. The Directors and administrative staff are involved in the administrative component of NESAC/BIO. Further details and specifics of the individual roles for each person in NESAC/BIO are provided on the following pages as well as in the TRD and Collaboration sections. The UW is long-standing supporter of NESAC/BIO. In the summer of 2012 a new $75 million, state-of-the-art building for the Molecular Engineering and Sciences (MolES) Institute was completed in the heart of the UW Seattle campus. NESAC/BIO was given instrumentation, wet chemistry laboratory and office space in the new MolES building. NESAC/BIO moved into the MolES building during the summer of 2012, consolidating its operations that were previously split between the Chemical Engineering and Bioengineering buildings. This has lead to further streamlining of NESAC/BIO operations. Several of the Nanotechnology User Facility tools were also moved to the MolES building, providing NESAC/BIO with easy access to additional instrumentation such as ellipsometry, confocal microscopy, transmission electron microscopy and scanning electron microscopy. In addition to the new facilities, six different units at the UW provide significant matching funds ($390,000 for this proposal) for both salary support of NESAC/BIO personnel as well as equipment purchases. Further details along with a letter of commitment are provided in the following section. NESAC/BIO has a long history of efficient and productive operations. This experience combined with the new facilities and continuing support from the UW will be used to administer NESAC/BIO so it continues to provide the biomedical research community with cost-effective and efficient access to the latest state-of-the-art instrumentation, experimental methods and data analysis procedures for biomedical surface analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB002027-32
Application #
9480408
Study Section
Special Emphasis Panel (ZEB1-OSR-E (M2)P)
Program Officer
Lash, Tiffani Bailey
Project Start
2016-12-01
Project End
2019-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
32
Fiscal Year
2017
Total Cost
$1,027,318
Indirect Cost
$352,319
Name
University of Washington
Department
Biomedical Engineering
Type
Domestic Higher Education
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Johansson, Patrik K; Schmüser, Lars; Castner, David G (2018) Nonlinear Optical Methods for Characterization of Molecular Structure and Surface Chemistry. Top Catal 61:1101-1124
Powell, C J; Werner, W S M; Kalbe, H et al. (2018) Comparisons of Analytical Approaches for Determining Shell Thicknesses of Core-Shell Nanoparticles by X-ray Photoelectron Spectroscopy. J Phys Chem C Nanomater Interfaces 122:4073-4082
Nguyen, Phuong A H; Stapleton, Lyndsay; Ledesma-Mendoza, Adrian et al. (2018) Exploring the anomalous cytotoxicity of commercially-available poly(N-isopropyl acrylamide) substrates. Biointerphases 13:06D406
Iqbal, Zohora; Moses, Willieford; Kim, Steven et al. (2018) Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices. J Biomed Mater Res B Appl Biomater 106:2327-2336
Chouirfa, Hamza; Evans, Margaret D M; Bean, Penny et al. (2018) Grafting of Bioactive Polymers with Various Architectures: A Versatile Tool for Preparing Antibacterial Infection and Biocompatible Surfaces. ACS Appl Mater Interfaces 10:1480-1491
Bluestein, Blake M; Morrish, Fionnuala; Graham, Daniel J et al. (2018) Analysis of the Myc-induced pancreatic ? cell islet tumor microenvironment using imaging ToF-SIMS. Biointerphases 13:06D402
Castner, David G (2018) Surface Analysis: From Single Crystals to Biomaterials. Surf Interface Anal 50:981-990
Killian, Manuela S; Taylor, Adam J; Castner, David G (2018) Stabilization of dry protein coatings with compatible solutes. Biointerphases 13:06E401
Roeters, Steven J; Tronic, Elaine H; Baio, Joe E et al. (2018) Structure of von Willebrand factor A1 on polystyrene determined from experimental and calculated sum frequency generation spectra. Biointerphases 13:06E411
Taylor, Michael J; Aitchison, Hannah; Hawker, Morgan J et al. (2018) Time of flight secondary ion mass spectrometry-A method to evaluate plasma-modified three-dimensional scaffold chemistry. Biointerphases 13:03B415

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