The mission for the NIH BioMEMS Resource Center (BMRC) is to bridge between microelectromechanicai systems (MEMS) and biomedical community to provide powerful microtechnologies to biomedical and clinical investigators. At its inception, the focus of the BMRC research was on the development of microfluidic chips for cell sorting, especially for fractionation of blood into its key components as well as the creation of living single cell arrays. In 2008, BMRC was renewed to expand its research portfolio to include rare cells with tremendous clinical potential, and more complex dynamic tissue microarrays. As we lool

Public Health Relevance

MRC continues to represent a significant potential for biomedical advances through its mission to develop and disseminate innovative microtechnologies with a broad range of applications varying from diagnostics, therapeutics, biomarker discovery, drug screening to disease models.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZEB1)
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Hunziker, Rosemarie
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Massachusetts General Hospital
United States
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Park, Myoung-Hwan; Reátegui, Eduardo; Li, Wei et al. (2017) Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip. J Am Chem Soc 139:2741-2749
Dang, Irène; Linkner, Joern; Yan, Jun et al. (2017) The Arp2/3 inhibitory protein Arpin is dispensable for chemotaxis. Biol Cell 109:162-166
Fachin, Fabio; Spuhler, Philipp; Martel-Foley, Joseph M et al. (2017) Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells. Sci Rep 7:10936
Jalali, Fatemeh; Ellett, Felix; Irimia, Daniel (2017) Rapid antibiotic sensitivity testing in microwell arrays. Technology (Singap World Sci) 5:107-114
Chandrasekaran, Arvind; Ellett, Felix; Jorgensen, Julianne et al. (2017) Temporal gradients limit the accumulation of neutrophils towards sources of chemoattractant. Microsyst Nanoeng 3:
Huang, Haishui; Yu, Yin; Hu, Yong et al. (2017) Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture. Lab Chip 17:1913-1932
Gokaltun, Aslihan; Yarmush, Martin L; Asatekin, Ayse et al. (2017) Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology. Technology (Singap World Sci) 5:1-12
Jiang, Xiaocheng; Wong, Keith H K; Khankhel, Aimal H et al. (2017) Microfluidic isolation of platelet-covered circulating tumor cells. Lab Chip 17:3498-3503
Frydman, Galit H; Le, Anna; Ellett, Felix et al. (2017) Technical Advance: Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay. J Leukoc Biol 101:797-806
Zhou, Renjie; Jin, Di; Hosseini, Poorya et al. (2017) Modeling the depth-sectioning effect in reflection-mode dynamic speckle-field interferometric microscopy. Opt Express 25:130-143

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