The mission for the NIH BioMEMS Resource Center (BMRC) is to bridge between microelectromechanicai systems (MEMS) and biomedical community to provide powerful microtechnologies to biomedical and clinical investigators. At its inception, the focus of the BMRC research was on the development of microfluidic chips for cell sorting, especially for fractionation of blood into its key components as well as the creation of living single cell arrays. In 2008, BMRC was renewed to expand its research portfolio to include rare cells with tremendous clinical potential, and more complex dynamic tissue microarrays. As we lool

Public Health Relevance

MRC continues to represent a significant potential for biomedical advances through its mission to develop and disseminate innovative microtechnologies with a broad range of applications varying from diagnostics, therapeutics, biomarker discovery, drug screening to disease models.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
2P41EB002503-11
Application #
8609426
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Hunziker, Rosemarie
Project Start
2004-04-01
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Jones, Caroline N; Dimisko, Laurie; Forrest, Kevin et al. (2016) Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus. J Infect Dis 213:465-75
Boneschansker, Leo; Nakayama, Hironao; Eisenga, Michele et al. (2016) Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo. J Immunol 197:1389-98
Prodanov, Ljupcho; Jindal, Rohit; Bale, Shyam Sundhar et al. (2016) Long-term maintenance of a microfluidic 3D human liver sinusoid. Biotechnol Bioeng 113:241-6
Wong, Keith H K; Sandlin, Rebecca D; Carey, Thomas R et al. (2016) The Role of Physical Stabilization in Whole Blood Preservation. Sci Rep 6:21023
Au, Sam H; Storey, Brian D; Moore, John C et al. (2016) Clusters of circulating tumor cells traverse capillary-sized vessels. Proc Natl Acad Sci U S A 113:4947-52
Sundaresan, Tilak K; Sequist, Lecia V; Heymach, John V et al. (2016) Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses. Clin Cancer Res 22:1103-10
Boneschansker, Leo; Inoue, Yoshitaka; Oklu, Rahmi et al. (2016) Capillary plexuses are vulnerable to neutrophil extracellular traps. Integr Biol (Camb) 8:149-55
Norling, Lucy V; Headland, Sarah E; Dalli, Jesmond et al. (2016) Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight 1:e85922
Richardson, Kirill; Bennion, Owen T; Tan, Shumin et al. (2016) Temporal and intrinsic factors of rifampicin tolerance in mycobacteria. Proc Natl Acad Sci U S A 113:8302-7
Skoge, Monica; Wong, Elisabeth; Hamza, Bashar et al. (2016) A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells. PLoS One 11:e0154491

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