The mission for the NIH BioMEMS Resource Center (BMRC) is to bridge between microelectromechanicai systems (MEMS) and biomedical community to provide powerful microtechnologies to biomedical and clinical investigators. At its inception, the focus of the BMRC research was on the development of microfluidic chips for cell sorting, especially for fractionation of blood into its key components as well as the creation of living single cell arrays. In 2008, BMRC was renewed to expand its research portfolio to include rare cells with tremendous clinical potential, and more complex dynamic tissue microarrays. As we lool

Public Health Relevance

MRC continues to represent a significant potential for biomedical advances through its mission to develop and disseminate innovative microtechnologies with a broad range of applications varying from diagnostics, therapeutics, biomarker discovery, drug screening to disease models.

Agency
National Institute of Health (NIH)
Type
Biotechnology Resource Grants (P41)
Project #
2P41EB002503-11
Application #
8609426
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Hunziker, Rosemarie
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Aranyosi, Alexander J; Wong, Elisabeth A; Irimia, Daniel (2015) A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis. Lab Chip 15:549-56
Bohr, Stefan; Patel, Suraj J; Vasko, Radovan et al. (2015) Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells. J Mol Med (Berl) 93:199-210
Luo, Xi; Mitra, Devarati; Sullivan, Ryan J et al. (2014) Isolation and molecular characterization of circulating melanoma cells. Cell Rep 7:645-53
Sullivan, James P; Nahed, Brian V; Madden, Marissa W et al. (2014) Brain tumor cells in circulation are enriched for mesenchymal gene expression. Cancer Discov 4:1299-309
Aceto, Nicola; Bardia, Aditya; Miyamoto, David T et al. (2014) Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell 158:1110-22
Boneschansker, Leo; Yan, Jun; Wong, Elisabeth et al. (2014) Microfluidic platform for the quantitative analysis of leukocyte migration signatures. Nat Commun 5:4787
Yan, Jun; Irimia, Daniel (2014) Stochastic variations of migration speed between cells in clonal populations. Technology (Singap World Sci) 2:185-188
Yu, Min; Bardia, Aditya; Aceto, Nicola et al. (2014) Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science 345:216-20
Wong, Ian Y; Javaid, Sarah; Wong, Elisabeth A et al. (2014) Collective and individual migration following the epithelial-mesenchymal transition. Nat Mater 13:1063-71
Cho, Hansang; Hamza, Bashar; Wong, Elisabeth A et al. (2014) On-demand, competing gradient arrays for neutrophil chemotaxis. Lab Chip 14:972-8

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