Hyperpolarized (HP) MRI using Dynamic Nuclear Polarization (DNP) is a powerful new imaging technique that uses specialized instrumentation to provide MR signal enhancement of 10,000-100,000 fold for C labeled compounds. To advance current hyperpolarized carbon-13 methodology, major advances in Dynamic Nuclear Polarization (DNP) instrumentation/methods and MR acquisition techniques are required to increase the applicability, reliability and information content of this emerging imaging technology. In conjunction with the Collaborative Project investigators and driven by the needs of their research projects, this Technology Research and Development (TR&D1) project is designed to: 1) develop and test new DNP polarizer hardware and techniques to produce higher, more robust liquid state polarizations (benefits all projects), 2) enable reliable multi-compound polarizations (with TR&D2, CP1-2, 3-7), and 3) develop robust MR acquisition techniques tailored to specific anatomic location, animal model, hyperpolarized molecule(s) and approach for all Collaborative Projects. The methods developed will also be disseminated to the Service Project investigators and to the broader HP research community via web documents and downloads. This TR&D1 project will be carried out by a multidisciplinary team with extensive expertise in basic NMR science, mechanical, electrical and instrumentation design, bioengineering, and DNP physics and engineering. In addition to this expertise, we have extensive facilities including mechanical and electronics shops, multiple NMR systems, MR scanners, and research DNP polarizers.
This project aims to advance significantly the performance, applicability, scope and information content of hyperpolarized MRI through novel instrumentation and technique development. These enhancements are designed to greatly improve the quality and productivity ofthe Collaborative Projects investigating improved methods for the clinical management of a wide range of human diseases.
|Zhang, Xiaoliang; Martin, Alastair; Jordan, Caroline et al. (2017) Design of catheter radio frequency coils using coaxial transmission line resonators for interventional neurovascular MR imaging. Quant Imaging Med Surg 7:187-194|
|Ragavan, Mukundan; Kirpich, Alexander; Fu, Xiaorong et al. (2017) A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design. Am J Physiol Heart Circ Physiol 312:H1215-H1223|
|Marco-Rius, Irene; von Morze, Cornelius; Sriram, Renuka et al. (2017) Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med 77:65-73|
|Marco-Rius, Irene; Cao, Peng; von Morze, Cornelius et al. (2017) Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies. Magn Reson Med 77:1419-1428|
|von Morze, Cornelius; Tropp, James; Chen, Albert P et al. (2017) Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo. Magn Reson Med :|
|Baligand, Celine; Qin, Hecong; True-Yasaki, Aisha et al. (2017) Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed 30:|
|Aggarwal, Rahul; Vigneron, Daniel B; Kurhanewicz, John (2017) Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer. Eur Urol 72:1028-1029|
|Chen, Hsin-Yu; Larson, Peder E Z; Bok, Robert A et al. (2017) Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res 77:3207-3216|
|Milshteyn, Eugene; von Morze, Cornelius; Reed, Galen D et al. (2017) Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques. Magn Reson Imaging 38:152-162|
|Guglielmetti, Caroline; Najac, Chloé; Didonna, Alessandro et al. (2017) Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A 114:E6982-E6991|
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