The Massachusetts Institute of Technology (MIT) Laser Biomedical Research Center (LBRC) requests NIH funding support for 26-30 years of operation. Under the leadership of its new Director, Dr. Peter So, LBRC will provide integrative photonic solutions to complex problems in biological research, pharmaceutical development, and medical diagnosis. Dr. So will be assisted by three Associated Directors: Drs. Ramachandra Dasari, Moungi Bawendi, and Andrie Tokmakoff. These senior investigators have a broad range of biophotonics expertise allowing LBRC to put forth three Technology Research and Development Projects proposing new biophotonic methods in the areas of (1) flurosecence instrumentation and probe, (2) phase-resolved spectroscopy and imaging, and (3) Raman and two-dimensional infrared spectroscopies. These TR&D projects are design to create new biophotonic tools for our collaborators to tackle important biomedical research problems in their respective fields. LBRC feature eight of these Driving Biomedical Projects covering the study of molecular and cell biology, neurobiology, cancer biology, diabetes diagnosis, and infectious disease treatment. In addition, LBRC also serve the biomedical community by disseminate matured technologies developed in the center. LBRC feature seven Collaborative Projects covering areas ranging from cancer, immunology, to tissue regeneration. Among these fifteen projects, half of these projects are led by investigators who have collaborated with LBRC in the past. The other half of these projects involves new researchers and new scientists. About 30 percent of these projects are conducted by teams led by clinicians. The rest of the projects are led by biologists or bioengineers. In additoin to research, collaboration and service, LBRC will also pursue a broad spectrum of activies in the dissemination of biophotonics technologies in the center and to train biomedical researcher in their uses. For the past 25 years, the success of LBRC has been built on research excellence and our ability to train stellar classes of biophotonics researchers. We look forward to carry on our mission and serve the biomedical community for the next five years.

Public Health Relevance

The LBRC develops integrative photonic solutions to complex problems in biological research, pharmaceutical development, and medical diagnosis problems including: cancer diagnosis and treatment;non-invasive glucose sensing;malaria detection;regenerative medicine;and gastric diseases. The success of LBRC has been built on its research excellence and the ability to train stellar biophotonics and biomedical spectroscopy researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
9P41EB015871-26A1
Application #
8268774
Study Section
Special Emphasis Panel (ZRG1-SBIB-S (40))
Program Officer
Conroy, Richard
Project Start
1997-06-01
Project End
2017-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
26
Fiscal Year
2012
Total Cost
$1,401,252
Indirect Cost
$404,908
Name
Massachusetts Institute of Technology
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Jin, Di; Sung, Yongjin; Lue, Niyom et al. (2017) Large population cell characterization using quantitative phase cytometer. Cytometry A 91:450-459
Abshire, James R; Rowlands, Christopher J; Ganesan, Suresh M et al. (2017) Quantification of labile heme in live malaria parasites using a genetically encoded biosensor. Proc Natl Acad Sci U S A 114:E2068-E2076
Bruns, Oliver T; Bischof, Thomas S; Harris, Daniel K et al. (2017) Next-generation in vivo optical imaging with short-wave infrared quantum dots. Nat Biomed Eng 1:
Yannas, Ioannis V; Tzeranis, Dimitrios S; So, Peter T C (2017) Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation. Wound Repair Regen 25:177-191
Hosseini, Poorya; Jin, Di; Yaqoob, Zahid et al. (2017) Single-shot dual-wavelength interferometric microscopy. Methods :
Winnard Jr, Paul T; Zhang, Chi; Vesuna, Farhad et al. (2017) Organ-specific isogenic metastatic breast cancer cell lines exhibit distinct Raman spectral signatures and metabolomes. Oncotarget 8:20266-20287
Ni, Ming; Zhuo, Shuangmu; So, Peter T C et al. (2017) Fluorescent probes for nanoscopy: four categories and multiple possibilities. J Biophotonics 10:11-23
Zheng, Cheng; Zhou, Renjie; Kuang, Cuifang et al. (2017) Digital micromirror device-based common-path quantitative phase imaging. Opt Lett 42:1448-1451
Rowlands, Christopher J; Park, Demian; Bruns, Oliver T et al. (2017) Wide-field three-photon excitation in biological samples. Light Sci Appl 6:e16255
Wei, He; Bruns, Oliver T; Kaul, Michael G et al. (2017) Exceedingly small iron oxide nanoparticles as positive MRI contrast agents. Proc Natl Acad Sci U S A 114:2325-2330

Showing the most recent 10 out of 110 publications