The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in Biology and Medicine. LAMMP is located within the Beckman Laser Institute and Medical Clinic, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. LAMMP activities span from basic science and technology development to clinical translational research. This is accomplished by combining state of the art Biophotonics technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinica care. LAMMP programs include Biophotonics modeling and technology development, basic science studies, instrument prototyping, and device testing in humans and animal models. Because of our facilities, resources, and expertise, we are able to rapidly move new concepts and technologies from blackboard to bench-top to bedside. In this seventh renewal application of LAMMP, we continue to transform our center by advancing several new technologies and high-impact collaborations. We propose to consolidate our activities into 4 major areas of Technology Research and Development (TR&D): Virtual Photonics Technologies (VPT), Microscopy and Microbeam Technologies (MMT), Multimodality Endoscopic Technologies (MET), and Diffuse Optics Technologies (DOT).
Specific Aims are proposed for each TR&D core that will result in the development of several state-of-the-art technologies, instruments, and computational methods. Together, the four TR&D cores contain complementary, inter-dependent approaches for quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Our broad goal is to advance these technologies through collaboration, service, training, and dissemination activities so they become widely-available, enabling methods for solving important problems in Biology and Medicine.
LAMMP basic science and technology discoveries are developed in a multidisciplinary environment and rapidly moved from blackboard to bench-top to bedside. New methods and devices are proposed that have direct relevance in detecting and treating cancer, vascular and neurologic diseases, and metabolic disorders, as well as providing new insights on fundamental biological processes, such as mechano-transduction, wound repair, angiogenesis, and cell death.
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|Ajose-Popoola, Olubunmi; Su, Erica; Hamamoto, Ashley et al. (2017) Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography. Laryngoscope 127:64-69|
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|Christie, Catherine; Pomeroy, Aftin; Nair, Rohit et al. (2017) Photodynamic therapy enhances the efficacy of gene-directed enzyme prodrug therapy. Photodiagnosis Photodyn Ther 18:140-148|
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|Jing, Joseph C; Chen, Jason J; Chou, Lidek et al. (2017) Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography. Sci Rep 7:8522|
|Hagen, Solveig L; Grey, Katherine R; Korta, Dorota Z et al. (2017) Quality of life in adults with facial port-wine stains. J Am Acad Dermatol 76:695-702|
|Hsieh, Jessica Y; Smith, Tim D; Meli, Vijaykumar S et al. (2017) Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomater 47:14-24|
|Hirschberg, Henry; Madsen, Steen J (2017) Cell Mediated Photothermal Therapy of Brain Tumors. J Neuroimmune Pharmacol 12:99-106|
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