In the armamentarium of techniques available for contemporary biomedical research carried out with humans at the basic, translational, and clinical level, magnetic resonance (MR) methods have become critical and indispensible, often providing non-invasive measurement capabilities that are simply unavailable from alternative approaches. The central aim of this Biotechnology Research Center (BTRC) grant is to significantly advance such MR based measurement capabilities and their biomedical applications in humans by: 1) developing novel image acquisition and reconstruction technologies and engineering solutions through five TRD (Technology Research and Development) projects, and 2) enabling a large number of Collaborative and Service projects to acquire advanced structural, functional, and physiological information to investigate human organ function in health and disease, targeting both human brain and the abdominal organs. This central aim will be pursued with a focus on high (3 and 4 Tesla) and particularly ultrahigh (7 Tesla and higher) magnetic fields, which provide numerous advantages but also pose several significant technological challenges that must be overcome. This is a unique feature and a particular strength of this BTRC;ultrahigh field MR and numerous accompanying methods for human studies were pioneered in this BTRC, yielding previously unavailable detection sensitivity and precision. This BTRC is also home to some of the most advanced, unique and rare high field MR instrumentation in the world. Collectively, these unique instruments and the proposed methodological developments are expected to be transformative for MR technology and its applications.

Public Health Relevance

Magnetic resonance (MR) imaging is a non-invasive is method that can be used for clinical, preclinical, translational and basic research studies with humans. This grant aims to significantly advance the capabilities of the MR technique through new technological developments and engineering solutions, targeting studies of function and circuitry of the human brain, and physiology of the heart, kidney, and prostate of the human abdomen.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZEB1-OSR-E (J2))
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Liu, Christina
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Liu, Jiaen; Zhang, Xiaotong; Schmitter, Sebastian et al. (2015) Gradient-based electrical properties tomography (gEPT): A robust method for mapping electrical properties of biological tissues in vivo using magnetic resonance imaging. Magn Reson Med 74:634-46
Deelchand, Dinesh K; Adanyeguh, Isaac M; Emir, Uzay E et al. (2015) Two-site reproducibility of cerebellar and brainstem neurochemical profiles with short-echo, single-voxel MRS at 3T. Magn Reson Med 73:1718-25
Corum, Curtis A; Idiyatullin, Djaudat; Snyder, Carl J et al. (2015) Gap cycling for SWIFT. Magn Reson Med 73:677-82
Kobayashi, Naoharu; Idiyatullin, Djaudat; Corum, Curt et al. (2015) SWIFT MRI enhances detection of breast cancer metastasis to the lung. Magn Reson Med 73:1812-9
Deelchand, Dinesh Kumar; Henry, Pierre-Gilles; Marja?ska, Ma?gorzata (2015) Effect of carr-purcell refocusing pulse trains on transverse relaxation times of metabolites in rat brain at 9.4 Tesla. Magn Reson Med 73:13-20
Liimatainen, Timo; Hakkarainen, Hanne; Mangia, Silvia et al. (2015) MRI contrasts in high rank rotating frames. Magn Reson Med 73:254-62
Kalavagunta, Chaitanya; Zhou, Xiangmin; Schmechel, Stephen C et al. (2015) Registration of in vivo prostate MRI and pseudo-whole mount histology using Local Affine Transformations guided by Internal Structures (LATIS). J Magn Reson Imaging 41:1104-14
Powell, Nathaniel J; Jang, Albert; Park, Jang-Yeon et al. (2015) Gradient rotating outer volume excitation (GROOVE): A novel method for single-shot two-dimensional outer volume suppression. Magn Reson Med 73:139-49
Gillick, Bernadette T; Krach, Linda E; Feyma, Tim et al. (2014) Primed low-frequency repetitive transcranial magnetic stimulation and constraint-induced movement therapy in pediatric hemiparesis: a randomized controlled trial. Dev Med Child Neurol 56:44-52
Kalavagunta, Chaitanya; Michaeli, Shalom; Metzger, Gregory J (2014) In vitro Gd-DTPA relaxometry studies in oxygenated venous human blood and aqueous solution at 3 and 7?T. Contrast Media Mol Imaging 9:169-76

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