Medical imaging has revolutionized clinical medicine. The development and deployment of modern medical imaging, barely 30 years ago, has been nothing short of stunning. The basic sciences have seen parallel technical developments with similar impact. The enormous resources applied to the clinical domain have pushed technology to higher resolution, specificity, and speed. The explosive growth of methods can overwhelm us with options and data. The goal of the Center for in Vivo Microscopy (CIVM) is to develop novel preclinical imaging tools and make these methods widely available to collaborators in the basic sciences.

Public Health Relevance

We propose here the next generation of preclinical imaging in which we will develop multimodality protocols that integrate the best of all the modalities to provide comprehensive insight into three major diseases - neurological disease, cardiovascular disease, and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015897-25
Application #
8696862
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Liu, Christina
Project Start
1997-09-30
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
25
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
City
Durham
State
NC
Country
United States
Zip Code
27705
Xie, Luke; Layton, Anita T; Wang, Nian et al. (2016) Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function. Am J Physiol Renal Physiol 310:F174-82
Virgincar, Rohan S; Robertson, Scott H; Nouls, John et al. (2016) Establishing an accurate gas phase reference frequency to quantify (129) Xe chemical shifts in vivo. Magn Reson Med :
Theis, Thomas; Ortiz Jr, Gerardo X; Logan, Angus W J et al. (2016) Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags. Sci Adv 2:e1501438
Robertson, Scott H; Virgincar, Rohan S; Bier, Elianna A et al. (2016) Uncovering a third dissolved-phase (129)Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis. Magn Reson Med :
Wang, Chunhao; Subashi, Ergys; Liang, Xiao et al. (2016) Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study. Phys Med Biol 61:4763-80
Fischer, Martin C; Wilson, Jesse W; Robles, Francisco E et al. (2016) Invited Review Article: Pump-probe microscopy. Rev Sci Instrum 87:031101
Wang, Chunhao; Subashi, Ergys; Yin, Fang-Fang et al. (2016) Dynamic fractal signature dissimilarity analysis for therapeutic response assessment using dynamic contrast-enhanced MRI. Med Phys 43:1335-47
Wang, Xiaoming; Bey, Alexandra L; Katz, Brittany M et al. (2016) Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun 7:11459
Touch, Mengheng; Clark, Darin P; Barber, William et al. (2016) A neural network-based method for spectral distortion correction in photon counting x-ray CT. Phys Med Biol 61:6132-53
Peterson, David E; Chen, Steven D; Calabrese, Evan et al. (2016) Automated segmentation of the canine corpus callosum for the measurement of diffusion tensor imaging. Neuroradiol J 29:4-12

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