We are requesting continuation of funds for the National Biomedical Resource Center in Image-guided Therapy (NCIGT) at the Brigham &Women's Hospital. The Center provides a unique, centralized infrastructure for translational research in the area of image-guided therapy. The multidisciplinary program involves clinical investigators, biomedical engineers, and basic scientists in promoting and advancing IGT methods and related innovative clinical applications. We will develop and make available new, clinically relevant technologies in six discrete TRD Core Projects: 1) Computational Core;2) Imaging Core;3) Image-Guidance Core;4) Neurosurgery Core;5) Prostate Core and 6) Focused Ultrasound Therapy Core. These key research initiatives represent the technical and clinical infrastructure of the Resource. They are anticipated to have significant effect on several future IGT methods and clinical applications. We will combine forces with 7 independently funded Collaborations (DBPs) that address various essential technical or clinical aspects of IGT and our contribution will have significant clinical impact. Our goal is to combine current advances in the field of imaging (like Molecular Imaging, Functional and Metabolic Imaging) with advanced therapies (like MRI-guided Focused Ultrasound ablation or targeted drug delivery, endoscopic surgery or robotics) to achieve less invasive, safer and more effective therapeutic options. All IGT developments and applications will be tested and validated either on our site or at our collaborators, or distributed directly as a service to the growing IGT community. Our overarching goal is to continue being the leading National Center that reaching effectively across a broad range of constituencies through service, training and dissemination of the novel technologies and methods under development In this Resource.

Public Health Relevance

The overarching impetus for this application is to advance and propagate novel image-guided therapy technologies, effectively producing strengthened multidisciplinary research efforts and an infrastructure commensurate with sophisticated technology development. We are also committed to making our technology broadly available to a large community of clinician. Our mission is to develop and implement novel, innovative technologies to decrease the invasiveness of surgeries and interventions.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-SBIB-L (40))
Program Officer
Krosnick, Steven
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Liao, Ruizhi; Ning, Lipeng; Chen, Zhenrui et al. (2017) Performance of unscented Kalman filter tractography in edema: Analysis of the two-tensor model. Neuroimage Clin 15:819-831
O'Donnell, Lauren J; Daducci, Alessandro; Wassermann, Demian et al. (2017) Advances in computational and statistical diffusion MRI. NMR Biomed :
Langkilde, Fredrik; Kobus, Thiele; Fedorov, Andriy et al. (2017) Evaluation of fitting models for prostate tissue characterization using extended-range b-factor diffusion-weighted imaging. Magn Reson Med :
Herrlich, Marc; Tavakol, Parnian; Black, David et al. (2017) Instrument-mounted displays for reducing cognitive load during surgical navigation. Int J Comput Assist Radiol Surg :
Chao, Tzu-Cheng; Chiou, Jr-Yuan George; Maier, Stephan E et al. (2017) Fast diffusion imaging with high angular resolution. Magn Reson Med 77:696-706
Chou, Shinn-Huey S; Gombos, Eva C; Chikarmane, Sona A et al. (2017) Computer-aided heterogeneity analysis in breast MR imaging assessment of ductal carcinoma in situ: Correlating histologic grade and receptor status. J Magn Reson Imaging 46:1748-1759
Luo, Ma; Frisken, Sarah F; Weis, Jared A et al. (2017) Retrospective study comparing model-based deformation correction to intraoperative magnetic resonance imaging for image-guided neurosurgery. J Med Imaging (Bellingham) 4:035003
Kamran, Sophia C; Manuel, Matthias M; Cho, Linda P et al. (2017) Comparison of outcomes for MR-guided versus CT-guided high-dose-rate interstitial brachytherapy in women with locally advanced carcinoma of the cervix. Gynecol Oncol 145:284-290
Herz, Christian; Fillion-Robin, Jean-Christophe; Onken, Michael et al. (2017) dcmqi: An Open Source Library for Standardized Communication of Quantitative Image Analysis Results Using DICOM. Cancer Res 77:e87-e90
Essayed, Walid I; Zhang, Fan; Unadkat, Prashin et al. (2017) White matter tractography for neurosurgical planning: A topography-based review of the current state of the art. Neuroimage Clin 15:659-672

Showing the most recent 10 out of 241 publications