Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by nearly two orders of magnitude, enabling microscopic, three-dimensional imaging over large fields-of-view, a capability that cannot be provided by conventional imaging or histology. Viewed across the entire range of biological and clinical applications, the opportunity presented by OCT technology is immense. State-of-the-art OCT technology, however, is not widely available to the biological and clinical communities. The few commercial systems that are available don't integrate recent advances and don't permit customization to new biomedical applications. Additionally, the technical complexity of OCT is a barrier to implementation and innovation outside of a limited number of technical academic research groups and these groups have been focused on a narrow sector of the potential applications in biology and medicine. The overriding motivation of this proposed Resource is to address the deficient accessibility of cutting-edge OCT instrumentation and technology. We propose to meet this need through the innovation of new technical capabilities that are motivated by significant biological and clinical challenges, and through translation, facilitated by direct collaboration. To launch the Resource, we have initiated six driving biomedical projects (DBPs) and through extensive discussions have jointly identified specific technical projects that will have significant biological and clinical impact. Projects that could serve more than one DBF or that represented a synergistic combination were identified to be particularly attractive for the initial efforts of the Resource. The selected projects naturally fall into three core thematic areas: advanced structural imaging, functional and compositional contrast, and hvbrid imaoino modalities.

Public Health Relevance

The proposed Resource will develop and provide broad access to powerful new microscopic imaging tools for biological and clinical research. These instruments will open new avenues of biomedical research and may enable the identification of new methods for diagnosis, provide new insights into disease or disease progression, or lead to the formulation of new therapeutic strategies or drug targets.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
8P41EB015903-02
Application #
8305476
Study Section
Special Emphasis Panel (ZRG1-SBIB-L (40))
Program Officer
Conroy, Richard
Project Start
2011-07-21
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$1,240,475
Indirect Cost
$495,452
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Meijer, Eelco F J; Blatter, Cedric; Chen, Ivy X et al. (2017) Lymph node effective vascular permeability and chemotherapy uptake. Microcirculation 24:
Khoueir, Ziad; Jassim, Firas; Poon, Linda Yi-Chieh et al. (2017) Diagnostic Capability of Peripapillary Three-dimensional Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans. Am J Ophthalmol 182:180-193
Khazaeinezhad, Reza; Siddiqui, Meena; Vakoc, Benjamin J (2017) 16??MHz wavelength-swept and wavelength-stepped laser architectures based on stretched-pulse active mode locking with a single continuously chirped fiber Bragg grating. Opt Lett 42:2046-2049
Lo, William C Y; Uribe-Patarroyo, Néstor; Nam, Ahhyun S et al. (2017) Laser thermal therapy monitoring using complex differential variance in optical coherence tomography. J Biophotonics 10:84-91
Meijer, Eelco F J; Jeong, Han-Sin; Pereira, Ethel R et al. (2017) Murine chronic lymph node window for longitudinal intravital lymph node imaging. Nat Protoc 12:1513-1520
Blatter, Cedric; Meijer, Eelco F J; Padera, Timothy P et al. (2017) Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography. J Biophotonics :
Yun, Seok Hyun; Kwok, Sheldon J J (2017) Light in diagnosis, therapy and surgery. Nat Biomed Eng 1:
Humar, Matjaž; Upadhya, Avinash; Yun, Seok Hyun (2017) Spectral reading of optical resonance-encoded cells in microfluidics. Lab Chip 17:2777-2784
Humar, Matjaž; Yun, Seok Hyun (2017) Whispering-gallery-mode emission from biological luminescent protein microcavity assemblies. Optica 4:222-228
Kassani, Sahar Hosseinzadeh; Villiger, Martin; Uribe-Patarroyo, Néstor et al. (2017) Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging. Opt Express 25:8255-8266

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