Abstract

5. Driving Biological Projects Abstract We will collaborate on a series of challenging biomedical research projects with outside investigators. These projects will drive the technology development and the TRDs in turn are anticipated to provide significant benefits to the biological research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
2P41GM103310-17
Application #
9275147
Study Section
Special Emphasis Panel (ZRG1-CB-R (40)P)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
17
Fiscal Year
2017
Total Cost
$205,618
Indirect Cost
$94,473

  Institution

Name
New York Structural Biology Center
Department
Type
Research Institutes
DUNS #
011191520
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Baldwin, Philip R; Tan, Yong Zi; Eng, Edward T et al. (2018) Big data in cryoEM: automated collection, processing and accessibility of EM data. Curr Opin Microbiol 43:1-8
Lopez-Redondo, Maria Luisa; Coudray, Nicolas; Zhang, Zhening et al. (2018) Structural basis for the alternating access mechanism of the cation diffusion facilitator YiiP. Proc Natl Acad Sci U S A 115:3042-3047
Cheng, Anchi; Eng, Edward T; Alink, Lambertus et al. (2018) High resolution single particle cryo-electron microscopy using beam-image shift. J Struct Biol 204:270-275
Kim, Laura Y; Rice, William J; Eng, Edward T et al. (2018) Benchmarking cryo-EM Single Particle Analysis Workflow. Front Mol Biosci 5:50
Zhang, Zhening; Liang, Wenguang G; Bailey, Lucas J et al. (2018) Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife 7:
Twomey, Edward C; Yelshanskaya, Maria V; Vassilevski, Alexander A et al. (2018) Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron 99:956-968.e4
Stewart-Jones, Guillaume B E; Chuang, Gwo-Yu; Xu, Kai et al. (2018) Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4. Proc Natl Acad Sci U S A 115:12265-12270
Xu, Kai; Acharya, Priyamvada; Kong, Rui et al. (2018) Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat Med 24:857-867
Bepler, Tristan; Morin, Andrew; Noble, Alex J et al. (2018) Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs. Res Comput Mol Biol 10812:245-247
Rice, William J; Cheng, Anchi; Noble, Alex J et al. (2018) Routine determination of ice thickness for cryo-EM grids. J Struct Biol 204:38-44

Showing the most recent 10 out of 159 publications