Maximizing the impact of each DBP project requires frequent communication so that we fully understand the nature of the biological problem being addressed and that the collaborating investigator(s) fully understand the capabilities of each available technology. We will continue to work actively with the investigators of each DBP to optimize and implement the most effective experimental design for each project. Our metric for successful completion of a DBP project is publication and we expect to fully engage in authoring each manuscript. As such, we will likewise actively work with each DBP collaborator to design, construct, and revise manuscripts that we will target for publication in top journals.
We aim for every DBP project to generate at least one publication. This strategy will also aid in disseminating the center technologies to new audiences, those of the collaborator's biomedical specialty field. As each DBP in our portfolio progresses, we will actively seek out new projects. We expect that many new DBPs will naturally evolve from the proposed work listed under the C&S section as those projects continue to take form. We will also continue to proactively seek out leaders in the fields of metabolism and biomedicine across a broad geographical area to initiate DBP projects that synergize with our existing work. We will continue to maintain a high bar for acceptance of DBP projects by actively screening proposals and selecting only those that we deem to be the most challenging and high-impact.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
1P41GM108538-01A1
Application #
8998787
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2016-07-05
Project End
2021-06-30
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Tanimura, Nobuyuki; Liao, Ruiqi; Wilson, Gary M et al. (2018) GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism. Dev Cell 46:581-594.e4
Riley, Nicholas M; Sikora, Jacek W; Seckler, Henrique S et al. (2018) The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins. Anal Chem 90:8553-8560
Frost, Dustin C; Rust, Clayton J; Robinson, RenĂ£ A S et al. (2018) Increased N,N-Dimethyl Leucine Isobaric Tag Multiplexing by a Combined Precursor Isotopic Labeling and Isobaric Tagging Approach. Anal Chem 90:10664-10669
MacGilvray, Matthew E; Shishkova, Evgenia; Chasman, Deborah et al. (2018) Network inference reveals novel connections in pathways regulating growth and defense in the yeast salt response. PLoS Comput Biol 13:e1006088
Chen, Bingming; Zhong, Xuefei; Feng, Yu et al. (2018) Targeted MultiNotch MS3 Approach for Relative Quantification of N-Glycans Using Multiplexed Carbonyl-Reactive Isobaric Tags. Anal Chem 90:1129-1135
Vakirlis, Nikolaos; Hebert, Alex S; Opulente, Dana A et al. (2018) A Molecular Portrait of De Novo Genes in Yeasts. Mol Biol Evol 35:631-645
Hutchins, Paul D; Russell, Jason D; Coon, Joshua J (2018) LipiDex: An Integrated Software Package for High-Confidence Lipid Identification. Cell Syst 6:621-625.e5
Jha, Pooja; McDevitt, Molly T; Gupta, Rahul et al. (2018) Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species. Cell Syst 6:722-733.e6
Hebert, Alexander S; Prasad, Satendra; Belford, Michael W et al. (2018) Comprehensive Single-Shot Proteomics with FAIMS on a Hybrid Orbitrap Mass Spectrometer. Anal Chem 90:9529-9537
Mitok, Kelly A; Freiberger, Elyse C; Schueler, Kathryn L et al. (2018) Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion. J Biol Chem 293:5860-5877

Showing the most recent 10 out of 32 publications