There are three aims for the Training core of National Resource For Advanced NMR Technology BTRR: 1) to provide introductory workshops to train the next generation of scientists in the experimental practice of biomolecular NMR spectroscopy, 2) to provide advanced workshops to train the next generation of scientists in the development of sensitive hardware and techniques for biomolecular NMR spectroscopy, and 3) to train NMR practitioners in best practices for using state of the art NMR instrumentation and deploying the technologies we develop through the BTRR in their biomedical research applications. We will offer two formal, four-day training workshops a year. Over a two-year cycle, this will enable us to offer a workshop aligned with each TR&D program as well as a standalone workshop on more general con- cepts of RF technology, probe design, and construction. A particular focus of these workshops will be hands- on training with laboratory exercises and practicums using NMR instruments to ensure participants gain a working understanding of the diverse and interdisciplinary aspects of NMR technology, NMR spectroscopy, biomedical sample preparation, RF and magnet engineering, and cryogenics as needed for state of the art biomedical research applications. Through a collaboration with the National Center for Biomolecular NMR Data Processing and Analysis BTRR, workshop participants will also receive training in data analysis workflow, archiving, and best practices for data storage and dissemination. Applied elements of the workshops aligned with individual TR&D programs will be developed in collaboration with DBPs to demonstrate the technology. Our goal is to educate the next generation of NMR spectroscopists which will lead to a highly trained community of users and an online repository storing practical information on the topics of NMR technology, instrument testing and calibration, and state of the art experiments for the NMR community.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
1P41GM122698-01
Application #
9280018
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Florida State University
Department
Type
DUNS #
790877419
City
Tallahassee
State
FL
Country
United States
Zip Code
32306
von Morze, Cornelius; Reed, Galen D; Larson, Peder E et al. (2018) In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med 80:480-487
Dubroca, Thierry; Smith, Adam N; Pike, Kevin J et al. (2018) A quasi-optical and corrugated waveguide microwave transmission system for simultaneous dynamic nuclear polarization NMR on two separate 14.1?T spectrometers. J Magn Reson 289:35-44
Cao, Wei; Wang, Wei David; Xu, Hai-Sen et al. (2018) Exploring Applications of Covalent Organic Frameworks: Homogeneous Reticulation of Radicals for Dynamic Nuclear Polarization. J Am Chem Soc 140:6969-6977
von Morze, Cornelius; Merritt, Matthew E (2018) Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology. NMR Biomed :e3937
Wu, Cheng-Yang; Satapati, Santhosh; Gui, Wenjun et al. (2018) A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity. J Biol Chem 293:9604-9613
Gan, Zhehong; Hung, Ivan; Wang, Xiaoling et al. (2017) NMR spectroscopy up to 35.2T using a series-connected hybrid magnet. J Magn Reson 284:125-136
Keeler, Eric G; Michaelis, Vladimir K; Colvin, Michael T et al. (2017) 17O MAS NMR Correlation Spectroscopy at High Magnetic Fields. J Am Chem Soc 139:17953-17963
DeHaven, Baillie A; Tokarski 3rd, John T; Korous, Arthur A et al. (2017) Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy. Chemistry 23:8315-8319