This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Alzheimer's disease (AD) is one of a number of age-related neurodegenerative diseases. The cause is unknown, but patients often present with brain pathology of plaques and tangles and, even more importantly, cell death. Vascular defects have been linked to AD development. For example, elderly patients who have undergone a stroke or ischemic episode are 2 times more likely to develop AD than patients who have not. The effects of reduced blood flow on the main pathological peptide in the AD brain, amyloid beta (A?), has been documented in vitro and been linked to increased production. However, little is known about the vascular reactivity in AD, a more subtle defect which could contribute to cell death as the AD brain struggles to compensate for hypoxic episodes. In this work we employ spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) for non-contact intrinsic signal in vivo optical imaging of brain tissue composition and function. In SFDI, intrinsic chromophore concentrations of oxy- and deoxy-hemoglobin, water, and lipid, in addition to high-contrast wavelength-dependent maps of tissue scattering were recovered. Concurrent LSI acquisition yields average blood flow measurements. Together with inhaled gas challenges we measured baseline and dynamic changes in blood chromophore concentrations, blood flow, and brain tissue scattering in the AD triple transgenic and APP-/- mice.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001192-32
Application #
8362729
Study Section
Special Emphasis Panel (ZRG1-SBIB-L (40))
Project Start
2011-04-01
Project End
2012-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
32
Fiscal Year
2011
Total Cost
$23,339
Indirect Cost
Name
University of California Irvine
Department
Physiology
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
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