This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hydrogels are networks of hydrophilic polymer chains and can contain over 90% wt. water. Most hydrogel materials are very weak due to their high water contents. Our research group has developed a hydrogel material with both high water content (70-90%wt.) and high tensile strength. Our material consists of a poly(ethylene glycol) network interpenetrated with a crosslinked network of poly(acrylic acid). Upon formation of this interpenetrating polymer network, tensile modulus and stress at fracture increase by an order of magnitude compared to single networks of each polymer. We are interesting in using SAXS measurements to probe the structure of our interpenetrating polymer networks. These measurements will give us valuable information regarding the nature of the observed increase in mechanical strength as well as the polymer network mesh size. This structural data can be related directly to our experimentally observed mechanical and transport properties. An understanding of the mechanisms responsible for the enhanced strength of these IPN hydrogels will provide insights on how to synthesize high strength synthetic soft tissue replacements.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001209-32
Application #
8362223
Study Section
Special Emphasis Panel (ZRG1-BCMB-P (40))
Project Start
2011-03-01
Project End
2012-02-29
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
32
Fiscal Year
2011
Total Cost
$3,295
Indirect Cost
Name
Stanford University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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