This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Howell's group has found by microarray analysis that unique exosomal markers are over-expressed in cisplatin (DDP) resistant cells. Biochemical analysis of purified exosomes showed that resistant cells release exosomes that are significantly enriched in putative efflux transporters of DDP. The exosomes from DDP resistant cells also accumulate higher levels of DDP, raising the possibility that they maight be instrumental in the export of the drug from resistant cells (resistant cells are accumulation defective.)

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-CDF-2 (40))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Davalos, Dimitrios; Baeten, Kim M; Whitney, Michael A et al. (2014) Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol 75:303-8
Cleyrat, Cédric; Darehshouri, Anza; Steinkamp, Mara P et al. (2014) Mpl traffics to the cell surface through conventional and unconventional routes. Traffic 15:961-82
Dowding, J M; Song, W; Bossy, K et al. (2014) Cerium oxide nanoparticles protect against A?-induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ 21:1622-32
Wilke, Scott A; Raam, Tara; Antonios, Joseph K et al. (2014) Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PLoS One 9:e84349
Cone, Angela C; Cavin, Gabriel; Ambrosi, Cinzia et al. (2014) Protein kinase C?-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem 289:8781-98
Ková?ik, Lubomír; Kereïche, Sami; Kerïeche, Sami et al. (2014) A simple Fourier filter for suppression of the missing wedge ray artefacts in single-axis electron tomographic reconstructions. J Struct Biol 186:141-52
Mottillo, Emilio P; Paul, George M; Moore, Hsiao-Ping H et al. (2014) Use of fluorescence microscopy to probe intracellular lipolysis. Methods Enzymol 538:263-78
Davis, Chung-ha O; Kim, Keun-Young; Bushong, Eric A et al. (2014) Transcellular degradation of axonal mitochondria. Proc Natl Acad Sci U S A 111:9633-8
Lee, Dongwook; Kim, Keun-Young; Shim, Myoung Sup et al. (2014) Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury. Apoptosis 19:603-14
Yu, Zeyun; Wang, Jun; Gao, Zhanheng et al. (2014) New software developments for quality mesh generation and optimization from biomedical imaging data. Comput Methods Programs Biomed 113:226-40

Showing the most recent 10 out of 328 publications