This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
SPECIFIC AIM 3 of CORE B Historical efforts by the CIVM to generate high-quality 129Xe MR images in animals have resulted in translation of this technology to the clinical arena. There now exists a clinical infrastructure for doing hyperpolarized 129Xe MRI in human subjects. This infrastructure uses a GE 1.5T scanner running at revision 14M5 and is currently imaging human ventilation using a multi slice gradient echo method. However, a critical aim in exploiting the most important properties of hyperpolarized 129Xe MRI is to directly image the 129Xe that enters in to the pulmonary blood stream. Such a method was first demonstrated by the CIVM in (B. Driehuys, G. P. Cofer, J. Pollaro et al., Proc. Natl. Acad. Sci. U. S. A. 103, 18278, 2006). It is now critically important to translate this method to the clinical setting. This is a specific aim our Core 2 of our P41 grant and is generally regarded in the field as the most important remaining technical step to realizing the full clinical potential of hyperpolarized 129Xe MRI. The core step needed to image 129Xe dissolved in pulmonary blood is to implement radial imaging on the clinical scanner. Radial imaging with its ultra short echo time is the key to imaging the short T2* signal of dissolved 129Xe in pulmonary tissues. This project proposes to use the infrastructure and talents of the CIVM to establish 3D radial imaging, with multi-nuclear capability on the clinial 1.5T scanner in the department of radiation oncology where current clinical 129Xe imaging is taking place. In addition to establishing the imaging sequence, this project also seeks to establish a robust pipeline for carrying out the reconstruction of the data. It will hence draw heavily on the expertise and talents of Gary Cofer for the pulse sequences and Sally Gewalt for the reconstruction. We will likely need the help of Lucy Upchurch to manage the necessary IT infrastructure that backs the reconstruction pipeline.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR005959-22
Application #
8363174
Study Section
Special Emphasis Panel (ZRG1-SBIB-P (40))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
22
Fiscal Year
2011
Total Cost
$6,136
Indirect Cost
Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Tang, Xinyan; Jing, Liufang; Richardson, William J et al. (2016) Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. J Orthop Res 34:1316-26
Hodgkinson, Conrad P; Bareja, Akshay; Gomez, José A et al. (2016) Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Circ Res 118:95-107
Schmeckpeper, Jeffrey; Verma, Amanda; Yin, Lucy et al. (2015) Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. J Mol Cell Cardiol 85:215-25
Roos, Justus E; McAdams, Holman P; Kaushik, S Sivaram et al. (2015) Hyperpolarized Gas MR Imaging: Technique and Applications. Magn Reson Imaging Clin N Am 23:217-29
He, Mu; Robertson, Scott H; Kaushik, S Sivaram et al. (2015) Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging 33:877-85
Huang, Jing; Guo, Jian; Beigi, Farideh et al. (2014) HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. J Mol Cell Cardiol 66:157-64
Huang, Lingling; Walter, Vonn; Hayes, D Neil et al. (2014) Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. Clin Cancer Res 20:1566-75
Yuan, Ying; Gilmore, John H; Geng, Xiujuan et al. (2014) FMEM: functional mixed effects modeling for the analysis of longitudinal white matter Tract data. Neuroimage 84:753-64
He, Mu; Kaushik, S Sivaram; Robertson, Scott H et al. (2014) Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI. Acad Radiol 21:1530-41
Liu, Chunlei; Li, Wei (2013) Imaging neural architecture of the brain based on its multipole magnetic response. Neuroimage 67:193-202

Showing the most recent 10 out of 239 publications