PROJECT 5: Nanotechnology-Based Environmental Sensing. Remediation of highly contaminated Superfund sites requires monitoring and evaluation of the contaminants themselves and their byproducts. Superfund sites have diverse and complex toxic species that contaminate soils, water and the surrounding air;determining what is there, and then determining the extent and effectiveness of remediation continue to present challenges. The rapid development of nanotechnology has offered significant opportunities to produce new sensors for the characterization and monitoring needs of Superfund, not only in the gas phase, but in the different environments where toxic and/or hazardous materials are produced or where they accumulate. We will take advantage of the unique properties of nanoscale materials to detect and measure species such as heavy metals. We plan to develop a collection of sensing protocols for the detection of arsenic, mercury and flame retardant compounds with high sensitivity and specificity. We will develop and apply small-molecule chemical indicators for fluorescence detection of mercury, lead, cadmium, and other toxic heavy metals in environmental laboratory and field samples, with specific interest in seafood and soil specimens. Parallel with this effort, plasmon absorption spectroscopy based on metal nanocrystals will be used for low-cost, rapid detection of mercury in air and aqueous environmental samples. We will continue to develop silver nanocrystal based substrates for ultra-sensitive arsenic detection using surface enhanced Raman spectroscopy. We will extend this sensing platform towards detecting chemical fingerprint for the analytes, distinguishing between the two most common oxidation states of arsenic: arsenate (As^) and arsenite (As'"""""""") both in ground water and some other complex media. Similariy this sensing scheme will be applied towards detection of methylated arsenic species with high sensitivity using small sample volume. In addition, we will also develop a sensitive and selective miniaturized electronic sensor for environmental toxicants molecules such as polybrominated diphenylethers (PBDE) using specific molecular recognition elements. These studies should provide new methods to detect and measure chemical and biological species at Superfund sites. The new methods will also be useful for assessing remediation efforts and the reduction of hazardous species at known sources.

Public Health Relevance

Novel sensing methods based on nanoscale materials could be deployed to gather more information about the extent of contamination as well as for verifying that cleanup methods are effective. Our proposal seeks to further explore the unique properties of materials on the nanoscale, and to exploit that knowledge to develop new sensing elements embodied in small molecules, nanoparticles and their ensembles. Our work focuses on the detection and quantification of heavy metals such as arsenic and mercury, and certain flame retardant compounds: these methods have the potential to be extended to other targets of interest.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004705-25
Application #
8382052
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
25
Fiscal Year
2012
Total Cost
$300,156
Indirect Cost
$83,879
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Counihan, Jessica L; Ford, Breanna; Nomura, Daniel K (2016) Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Curr Opin Chem Biol 30:68-76
Shen, Hua; McHale, Cliona M; Haider, Syed I et al. (2016) Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells. Toxicol Sci 154:194
Smith, Martyn T; Guyton, Kathryn Z; Gibbons, Catherine F et al. (2016) Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environ Health Perspect 124:713-21
Hsu, Ling-I; Briggs, Farren; Shao, Xiaorong et al. (2016) Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol Biomarkers Prev 25:815-22
Carlos-Wallace, Frolayne M; Zhang, Luoping; Smith, Martyn T et al. (2016) Parental, In Utero, and Early-Life Exposure to Benzene and the Risk of Childhood Leukemia: A Meta-Analysis. Am J Epidemiol 183:1-14
Liu, Haizhou; Bruton, Thomas A; Li, Wei et al. (2016) Oxidation of Benzene by Persulfate in the Presence of Fe(III)- and Mn(IV)-Containing Oxides: Stoichiometric Efficiency and Transformation Products. Environ Sci Technol 50:890-8
Barazesh, James M; Prasse, Carsten; Sedlak, David L (2016) Electrochemical Transformation of Trace Organic Contaminants in the Presence of Halide and Carbonate Ions. Environ Sci Technol 50:10143-52
Shen, Hua; McHale, Cliona M; Haider, Syed I et al. (2016) Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells. Toxicol Sci 151:10-22
Hu, Xindi C; Andrews, David Q; Lindstrom, Andrew B et al. (2016) Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants. Environ Sci Technol Lett 3:344-350
Bailey, Kathryn A; Smith, Allan H; Tokar, Erik J et al. (2016) Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps. Environ Health Perspect 124:170-5

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