PROJECT 5: Nanotechnology-Based Environmental Sensing. Remediation of highly contaminated Superfund sites requires monitoring and evaluation of the contaminants themselves and their byproducts. Superfund sites have diverse and complex toxic species that contaminate soils, water and the surrounding air;determining what is there, and then determining the extent and effectiveness of remediation continue to present challenges. The rapid development of nanotechnology has offered significant opportunities to produce new sensors for the characterization and monitoring needs of Superfund, not only in the gas phase, but in the different environments where toxic and/or hazardous materials are produced or where they accumulate. We will take advantage of the unique properties of nanoscale materials to detect and measure species such as heavy metals. We plan to develop a collection of sensing protocols for the detection of arsenic, mercury and flame retardant compounds with high sensitivity and specificity. We will develop and apply small-molecule chemical indicators for fluorescence detection of mercury, lead, cadmium, and other toxic heavy metals in environmental laboratory and field samples, with specific interest in seafood and soil specimens. Parallel with this effort, plasmon absorption spectroscopy based on metal nanocrystals will be used for low-cost, rapid detection of mercury in air and aqueous environmental samples. We will continue to develop silver nanocrystal based substrates for ultra-sensitive arsenic detection using surface enhanced Raman spectroscopy. We will extend this sensing platform towards detecting chemical fingerprint for the analytes, distinguishing between the two most common oxidation states of arsenic: arsenate (As^) and arsenite (As'") both in ground water and some other complex media. Similariy this sensing scheme will be applied towards detection of methylated arsenic species with high sensitivity using small sample volume. In addition, we will also develop a sensitive and selective miniaturized electronic sensor for environmental toxicants molecules such as polybrominated diphenylethers (PBDE) using specific molecular recognition elements. These studies should provide new methods to detect and measure chemical and biological species at Superfund sites. The new methods will also be useful for assessing remediation efforts and the reduction of hazardous species at known sources.

Public Health Relevance

Novel sensing methods based on nanoscale materials could be deployed to gather more information about the extent of contamination as well as for verifying that cleanup methods are effective. Our proposal seeks to further explore the unique properties of materials on the nanoscale, and to exploit that knowledge to develop new sensing elements embodied in small molecules, nanoparticles and their ensembles. Our work focuses on the detection and quantification of heavy metals such as arsenic and mercury, and certain flame retardant compounds: these methods have the potential to be extended to other targets of interest.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004705-26
Application #
8461215
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
26
Fiscal Year
2013
Total Cost
$281,406
Indirect Cost
$77,600
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Zhang, L; Samad, A; Pombo-de-Oliveira, M S et al. (2015) Global characteristics of childhood acute promyelocytic leukemia. Blood Rev 29:101-25
Gaytán, Brandon D; Vulpe, Chris D (2014) Functional toxicology: tools to advance the future of toxicity testing. Front Genet 5:110
McHale, Cliona M; Smith, Martyn T; Zhang, Luoping (2014) Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human. Ann N Y Acad Sci 1310:74-83
Ward, Mary H; Colt, Joanne S; Deziel, Nicole C et al. (2014) Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California. Environ Health Perspect 122:1110-6
Xiao, Jianqiao; Lee, Seung-Tae; Xiao, Yuanyuan et al. (2014) PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer 135:1101-9
Morris, Patrick J; Medina-Cleghorn, Daniel; Heslin, Ann et al. (2014) Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia. ACS Chem Biol 9:1097-103
Men, Yujie; Seth, Erica C; Yi, Shan et al. (2014) Sustainable growth of Dehalococcoides mccartyi 195 by corrinoid salvaging and remodeling in defined lactate-fermenting consortia. Appl Environ Microbiol 80:2133-41
Mehinto, Alvine C; Prucha, Melinda S; Colli-Dula, Reyna C et al. (2014) Gene networks and toxicity pathways induced by acute cadmium exposure in adult largemouth bass (Micropterus salmoides). Aquat Toxicol 152:186-94
Koster van Groos, Paul G; Esser, Bradley K; Williams, Ross W et al. (2014) Isotope effect of mercury diffusion in air. Environ Sci Technol 48:227-33
Thomas, Reuben; Hubbard, Alan E; McHale, Cliona M et al. (2014) Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure. PLoS One 9:e91828

Showing the most recent 10 out of 482 publications