Project 6: Oxidative Remediation of Recalcitrant Contaminants with Persulfate. Persulfate (S20s^) is a relatively inexpensive reagent that can be used to oxidize many of the most recalcitrant contaminants present at hazardous waste sites. Although it is becoming more popular for hazardous waste site remediation, the chemical reactions through which persulfate oxidizes contaminants are not well understood. The overall goal of our research is to develop and test new approaches for oxidizing contaminants that are difficult to treat with existing technologies (e.g., PCBs, 1,4-dioxane and PFOA) and apply it to make treatment systems more robust and efficient. Through the use of kinetic models and detailed research on reaction mechanisms, we will develop the means of predicting contaminant transformation rates and optimizing system performance. This mechanistic understanding of persulfate chemistry will require that we build increasing complexity into our model in stages. Initially, we will calibrate our kinetic model for the homogeneous reactions through which persulfate is converted into oxidants using experiments with various compounds that react predominantly with sulfate radical or hydroxyl radical. After calibrating the model over the range of conditions likely to be encountered during remediation, we will investigate the role of heterogeneous reactions of iron-containing solids on the initiation of radical production. By applying findings from experiments in heterogeneous systems with state-of-the-art surface characterization techniques we will synthesize new types of heterogeneous catalysts for ex situ treatment of contaminated groundwater. We also will use results from the heterogeneous experiments to improve the predictive ability ofthe model and identify optimal conditions for remediation. After defining the conditions that are best suited for contaminant remediation, we will assess the potential formation of toxic intermediate products during the remediation process using high content screening assays and mass spectrometry. Our research will lead to a mechanistic understanding of persulfate chemistry that should, in turn, lead to a level of understanding that will allow engineers to avoid excessive use of reagents and the formation of toxic intermediates when persulfate is used for remediation.

Public Health Relevance

Successful completion of the proposed research will result in new oxidative treatment systems that will substantially reduce the costs of remediating contaminants that are difficult to treat with existing technologies. Our research will also result in the development of a better understanding of when ISCO will be effective, thereby facilitating the broader application ofthe technology and a reduction in public health risks at hazardous waste sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004705-26
Application #
8461216
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
26
Fiscal Year
2013
Total Cost
$280,375
Indirect Cost
$88,517
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Smith, Allan H; Marshall, Guillermo; Roh, Taehyun et al. (2018) Lung, Bladder, and Kidney Cancer Mortality 40?Years After Arsenic Exposure Reduction. J Natl Cancer Inst 110:241-249
Castriota, Felicia; Acevedo, Johanna; Ferreccio, Catterina et al. (2018) Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile. Environ Res 167:248-254
Rothman, Nathaniel; Zhang, Luoping; Smith, Martyn T et al. (2018) Formaldehyde, Hematotoxicity, and Chromosomal Changes-Response. Cancer Epidemiol Biomarkers Prev 27:120-121
Yik-Sham Chung, Clive; Timblin, Greg A; Saijo, Kaoru et al. (2018) Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining. J Am Chem Soc 140:6109-6121
Rappaport, Stephen M (2018) Redefining environmental exposure for disease etiology. NPJ Syst Biol Appl 4:30
Tachachartvanich, Phum; Sangsuwan, Rapeepat; Ruiz, Heather S et al. (2018) Assessment of the Endocrine-Disrupting Effects of Trichloroethylene and Its Metabolites Using in Vitro and in Silico Approaches. Environ Sci Technol 52:1542-1550
Guyton, Kathryn Z; Rieswijk, Linda; Wang, Amy et al. (2018) Key Characteristics Approach to Carcinogenic Hazard Identification. Chem Res Toxicol :
Roh, Taehyun; Steinmaus, Craig; Marshall, Guillermo et al. (2018) Age at Exposure to Arsenic in Water and Mortality 30-40 Years After Exposure Cessation. Am J Epidemiol 187:2297-2305
Daniels, Sarah I; Chambers, John C; Sanchez, Sylvia S et al. (2018) Elevated Levels of Organochlorine Pesticides in South Asian Immigrants Are Associated With an Increased Risk of Diabetes. J Endocr Soc 2:832-841
Guyton, Kathryn Z; Rusyn, Ivan; Chiu, Weihsueh A et al. (2018) Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39:614-622

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