The Research Translation Core (RTC) will use effective methods to translate scientific findings and knowledge to those who can take actions to improve public health and protect the environment. The RTC incorporates partnerships with government agencies and communication strategies for broad audiences. a. Addressing the greater susceptibilities of infants and children to environmental exposures ~ Research by Berkeley SRP investigators and others demonstrates greater significance of exposures in early life to the development of disease. Incorporating consideration of critical life stages and susceptibilities into public policy is a critical need. We plan to collaborate with other researchers, US EPA, Cal EPA, and stakeholders to identify critical interventions that arise from the research to date, to translate findings for risk assessment, and to contribute to stable links between groups to amplify impact. b. Improving chemical testing and assessment methods ~ EPA Administrator Jackson has made chemical safety one of her priority areas. New findings and technologies could contribute to better methods to characterize hazards of chemicals at less cost, which would be valuable for assessment of existing Superfund sites and prevention of new ones. The RTC plans to partner with US EPA and Cal EPA to translate new findings in this context and inform our broad audiences through existing networks. c. Reducing cumulative impacts of multiple stressors on communities ~ This is a key priority for US EPA and the Superfund program. Most policy interventions for environmental factors focus on single pollutants. We plan to collaborate with individuals at US EPA Region 9, the Office of Research and Development and the Office of Environmental Justice to contribute to translation of research for methods to consider cumulative impacts of multiple stressors in decisions at the regional and national level. d. Improving remediation for mercury ~ Mercury is a pervasive contaminant ranked third highest among those present at National Priority List sites. Remediation of mercury at Superfund sites is thus a high priority but has had limited successes due to some ofthe unique properties and technological challenges of mercury. We plan to identify ways to over come these challenges. e. The research strategy incorporates paths for technology transfer for each research project. Investigators from Projects will also continue to participate in scientific advisory committees and expert panels and symposia organized by US EPA and other government agencies to transfer and transate scientific results.

Public Health Relevance

The RTC engages the Project Scientists in order to help bring our research to application, policy initiatives, and public awareness. The RTC will partner with local, state, and federal agencies and NGOs to design and implement strategies to translate scientific findings and knowledge on cross-cutting topics in ways that are relevant to their needs.

Agency
National Institute of Health (NIH)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004705-27
Application #
8659380
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Type
DUNS #
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Counihan, Jessica L; Ford, Breanna; Nomura, Daniel K (2016) Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Curr Opin Chem Biol 30:68-76
Shen, Hua; McHale, Cliona M; Haider, Syed I et al. (2016) Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells. Toxicol Sci 154:194
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Hsu, Ling-I; Briggs, Farren; Shao, Xiaorong et al. (2016) Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol Biomarkers Prev 25:815-22
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Barazesh, James M; Prasse, Carsten; Sedlak, David L (2016) Electrochemical Transformation of Trace Organic Contaminants in the Presence of Halide and Carbonate Ions. Environ Sci Technol 50:10143-52
Shen, Hua; McHale, Cliona M; Haider, Syed I et al. (2016) Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells. Toxicol Sci 151:10-22
Hu, Xindi C; Andrews, David Q; Lindstrom, Andrew B et al. (2016) Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants. Environ Sci Technol Lett 3:344-350
Bailey, Kathryn A; Smith, Allan H; Tokar, Erik J et al. (2016) Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps. Environ Health Perspect 124:170-5

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