The essence of the University of Arizona Superfund Basic Research Program (UA SBRP) renewal application is hazardous waste risk and remediation In the US Southwest. The theme of this Program Is to support development of a risk assessment process for metal and organic contaminants through toxicologic and hydrogeologic studies and innovative remediation technologies. Our application emphasizes hazardous waste issues in the Southwest (and Mexican Border) associated with the distinctive arid nature of the environment. Importantly, the outcomes of these studies can be extrapolated to arid environments around the world. Currently 1/3 of land surfaces are arid or semi arid and this proportion is expected to increase due to climate change. This is exemplified by the toxicants we study, metals (arsenic) and halogenated hydrocarbons, which are major contaminants in our region but also of significant concern throughout the world. Our Program consists of 9 research projects - five biomedical projects and four environmental sciences projects. Many of the projects are collaborative involving multiple disciplines. The biomedical projects are examining the mechanism of arsenic toxicity in target tissues, factors that affect the susceptibility of populations to arsenic-induced toxicity, and potential therapeutic approaches. The environmental sciences projects are investigating how hazardous wastes (arsenic, TCE/PCE) can be optimally characterized for risk assessment and remediation, and developing innovative techniques for assessing exposure and waste containment in our arid Southwest environment. These research projects are supported by five Cores that: administer the Program, translate the results to stakeholders, provide research services, promote unique outreach efforts to ethnic communities along the Border, and support graduate student training. This project will contribute to our understanding of toxicology and remediation of hazardous wastes nationally and internationally.

Public Health Relevance

This application emphasizes hazardous waste issues in the Southwest associated with the distinctive arid nature of the environment. Water is precious in arid environments and dust is ever present. Contamination of our water or soil by hazardous waste affects broad populations. We must assess the health risks, containment, and remediation of ubiquitous contaminants [metals (arsenic) and halogenated solvents] present in the arid Southwest and use this information for handling these contaminants at other sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES004940-24S1
Application #
8711960
Study Section
Special Emphasis Panel (ZES1-LWJ-M (O1))
Program Officer
Carlin, Danielle J
Project Start
2013-08-20
Project End
2014-03-31
Budget Start
2013-08-20
Budget End
2014-03-31
Support Year
24
Fiscal Year
2013
Total Cost
$10,000
Indirect Cost
Name
University of Arizona
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Mora, Marco; Braun, Rachel A; Shingler, Taylor et al. (2017) Analysis of remotely sensed and surface data of aerosols and meteorology for the Mexico Megalopolis Area between 2003 and 2015. J Geophys Res Atmos 122:8705-8723
Guo, Zhilin; Brusseau, Mark L (2017) The impact of well-field configuration and permeability heterogeneity on contaminant mass removal and plume persistence. J Hazard Mater 333:109-115
Zhang, Xiang; Gu, Xiaogang; Lu, Shuguang et al. (2017) Application of ascorbic acid to enhance trichloroethene degradation by Fe(III)-activated calcium peroxide. Chem Eng J 325:188-198
Danish, Muhammad; Gu, Xiaogang; Lu, Shuguang et al. (2017) An efficient catalytic degradation of trichloroethene in a percarbonate system catalyzed by ultra-fine heterogeneous zeolite supported zero valent iron-nickel bimetallic composite. Appl Catal A Gen 531:177-186
Ramos-Ruiz, Adriana; Sesma-Martin, Juan; Sierra-Alvarez, Reyes et al. (2017) Continuous reduction of tellurite to recoverable tellurium nanoparticles using an upflow anaerobic sludge bed (UASB) reactor. Water Res 108:189-196
Madeira, Camila L; Speet, Samuel A; Nieto, Cristina A et al. (2017) Sequential anaerobic-aerobic biodegradation of emerging insensitive munitions compound 3-nitro-1,2,4-triazol-5-one (NTO). Chemosphere 167:478-484
Honeker, Linnea K; Neilson, Julia W; Root, Robert A et al. (2017) Bacterial Rhizoplane Colonization Patterns of Buchloe dactyloides Growing in Metalliferous Mine Tailings Reflect Plant Status and Biogeochemical Conditions. Microb Ecol 74:853-867
Fu, Xiaori; Gu, Xiaogang; Lu, Shuguang et al. (2017) Benzene oxidation by Fe(III)-catalyzed sodium percarbonate: matrix constituent effects and degradation pathways. Chem Eng J 309:22-29
Olivares, Christopher I; Madeira, Camila L; Sierra-Alvarez, Reyes et al. (2017) Environmental Fate of 14C Radiolabeled 2,4-Dinitroanisole in Soil Microcosms. Environ Sci Technol 51:13327-13334
Soltani, Naghmeh; Keshavarzi, Behnam; Sorooshian, Armin et al. (2017) Oxidative potential (OP) and mineralogy of iron ore particulate matter at the Gol-E-Gohar Mining and Industrial Facility (Iran). Environ Geochem Health :

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