The UNC-CH Program's multidisciplinary research will address scientific issues that underpin the assessment and reduction of risks to human health associated with high priority chemicals at Superfund sites. The overall specific aims are to improve the scientific foundation for risk assessment, elucidate mechanisms responsible for inter-individual susceptibility, advance approaches to assessing exposure to hazardous chemicals, and more efficiently reduce risks by remediation of hazardous waste sites. In this competing continuation, we will focus on three major classes of chemicals ~ polycyclic aromatic hydrocarbons (PAHs), halogenated hydrocarbons, and heavy metals ~ in three biomedical and two non-biomedical projects, two Research Support Cores, a Research Translation Core (RTC), and an Administrative Core. Research themes that cross multiple projects and cores include: (1) developing biomarkers of exposure and effect for human and experimental models of environmental disease over a range of exposure levels to improve low-dose quantitative risk assessment;(2) applying new molecular tools in a systems biology framework to understand metabolic pathways critical for environmental disease, predict in vivo inter-individual differences in susceptibility and risk, and evaluate complex microbial communities in bioremediation systems;(3) using advanced analytical tools to identify mechanisms of genotoxicity;(4) using advanced statistical and bioinformatics methods to evaluate gene-environment interactions;and (5) quantifying the chronic exposure and bioavailability of toxic compounds in environmental systems. This work will also be integrated by sharing methods and resources across projects and cores, by regular meetings of all researchers, and by co-advising of trainees by faculty in different projects and cores. Working with investigators, the RTC will enhance the capacity of government agencies to provide technical assistance to communities, develop improved decision-support tools, and promote the commercialization of our research products. This Program is highly relevant to Superfund by addressing high-priority chemicals and by focusing on mechanisms underlying health effects, exposure assessment, and remediation to mitigate exposure and toxicity.
This Program is relevant to public health because it will develop better means of quantifying risks to human health from exposure to hazardous chemicals, provide a genetic basis for susceptibility to diseases caused by these chemicals, improve methods to monitor exposure, and advance methods of reducing risks through remediation of contaminated sites.
|Laine, Jessica E; Bailey, Kathryn A; Rubio-Andrade, Marisela et al. (2015) Maternal arsenic exposure, arsenic methylation efficiency, and birth outcomes in the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Mexico. Environ Health Perspect 123:186-92|
|Edwards, Sharon E; Maxson, Pamela; Miranda, Marie Lynn et al. (2015) Cadmium levels in a North Carolina cohort: Identifying risk factors for elevated levels during pregnancy. J Expo Sci Environ Epidemiol 25:427-32|
|Rojas, Daniel; Rager, Julia E; Smeester, Lisa et al. (2015) Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci 143:97-106|
|Bailey, Kathryn A; Fry, Rebecca C (2014) Arsenic-Associated Changes to the Epigenome: What Are the Functional Consequences? Curr Environ Health Rep 1:22-34|
|Hu, Jing; Adrion, Alden C; Nakamura, Jun et al. (2014) Bioavailability of (Geno)toxic Contaminants in Polycyclic Aromatic Hydrocarbon-Contaminated Soil Before and After Biological Treatment. Environ Eng Sci 31:176-182|
|Chiu, Weihsueh A; Campbell Jr, Jerry L; Clewell 3rd, Harvey J et al. (2014) Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse. Environ Health Perspect 122:456-63|
|Rusyn, Ivan; Lemon, Stanley M (2014) Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies? Cancer Lett 345:210-5|
|Lu, Sixin S; Sobus, Jon R; Sallsten, Gerd et al. (2014) Are urinary PAHs biomarkers of controlled exposure to diesel exhaust? Biomarkers 19:332-9|
|Nakamura, Jun; Mutlu, Esra; Sharma, Vyom et al. (2014) The endogenous exposome. DNA Repair (Amst) 19:3-13|
|Mishamandani, Sara; Gutierrez, Tony; Aitken, Michael D (2014) DNA-based stable isotope probing coupled with cultivation methods implicates Methylophaga in hydrocarbon degradation. Front Microbiol 5:76|
Showing the most recent 10 out of 329 publications