The Research Translation Core (RTC) focuses on improving scientific and public understanding of how Superfund chemicals harm human health and how to reduce exposure to those chemicals, enabling government officials and the public to make informed decisions about reducing risk. We emphasize the high priority Superfund chemicals studied within the UNC SRP. The RTC aims to: (1) foster and coordinate research translation efforts within UNC SRP and share our results with NIEHS and other SRPs, (2) raise awareness of UNC SRP research among federal, state and local government agencies and build their capacity to protect health and the environment around contaminated sites;(3) advance the practical contributions of our research through development of decision support tools and innovative environmental technology;(4) raise awareness among teachers and other broad audiences of UNC SRP research findings and general environmental health concepts related to hazardous chemical exposure;and (5) increase our students'knowledge of research translation concepts. The RTC will continue current efforts to raise awareness of UNC SRP research and extend them to new state agency partners. We will also implement new initiatives designed to respond to research needs identified by state agencies and local health departments in communities with hazardous waste sites. The RTC will continue to assist NCDENR and NCDHHS in creating decision making tools that index cumulative exposure to pollutants and health outcomes, refining beta versions of these tools and implementing new efforts to train agency staff in their use. We will also work with the UNC Office of Technology Development to assist researchers in the commercialization process. In addition, the RTC will continue and expand its teacher professional development activities, enabling us to effectively share Superfund related science with broad audiences in appropriate ways. We will also conduct short courses on research translation topics for Environmental Sciences and Engineering students.
RTC activities will enhance the capacity of federal/state/local agencies to provide technical assistance in communities with identified environmental health concerns. We will contribute to the development of improved decision support tools and cleanup technologies. We will also introduce teachers and others to environmental health concepts, preparing them and their students to make informed decisions in their lives.
|Martin, Elizabeth M; Stýblo, Miroslav; Fry, Rebecca C (2017) Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence. Epigenomics 9:701-710|
|Luo, Yu-Syuan; Cichocki, Joseph A; McDonald, Thomas J et al. (2017) Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatog J Toxicol Environ Health A 80:513-524|
|Grimm, Fabian A; Russell, William K; Luo, Yu-Syuan et al. (2017) Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across. Environ Sci Technol 51:7197-7207|
|Smeester, Lisa; Bommarito, Paige A; Martin, Elizabeth M et al. (2017) Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response. Environ Toxicol Pharmacol 52:183-187|
|McEachran, Andrew D; Shea, Damian; Nichols, Elizabeth Guthrie (2017) Pharmaceuticals in a temperate forest-water reuse system. Sci Total Environ 581-582:705-714|
|Huang, Madelyn C; Douillet, Christelle; Su, Mingming et al. (2017) Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Arch Toxicol 91:189-202|
|Zhou, Yi-Hui; Cichocki, Joseph A; Soldatow, Valerie Y et al. (2017) Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse. Toxicol Sci 160:95-110|
|Gao, Lina; Mutlu, Esra; Collins, Leonard B et al. (2017) DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. Chem Res Toxicol 30:794-803|
|Nakamura, Jun; Shimomoto, Takasumi; Collins, Leonard B et al. (2017) Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes. Sci Rep 7:10787|
|Brooks, Samira A; Fry, Rebecca C (2017) Cadmium inhibits placental trophoblast cell migration via miRNA regulation of the transforming growth factor beta (TGF-?) pathway. Food Chem Toxicol 109:721-726|
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