The Research Translation Core (RTC) focuses on improving scientific and public understanding of how Superfund chemicals harm human health and how to reduce exposure to those chemicals, enabling government officials and the public to make informed decisions about reducing risk. We emphasize the high priority Superfund chemicals studied within the UNC SRP. The RTC aims to: (1) foster and coordinate research translation efforts within UNC SRP and share our results with NIEHS and other SRPs, (2) raise awareness of UNC SRP research among federal, state and local government agencies and build their capacity to protect health and the environment around contaminated sites;(3) advance the practical contributions of our research through development of decision support tools and innovative environmental technology;(4) raise awareness among teachers and other broad audiences of UNC SRP research findings and general environmental health concepts related to hazardous chemical exposure;and (5) increase our students'knowledge of research translation concepts. The RTC will continue current efforts to raise awareness of UNC SRP research and extend them to new state agency partners. We will also implement new initiatives designed to respond to research needs identified by state agencies and local health departments in communities with hazardous waste sites. The RTC will continue to assist NCDENR and NCDHHS in creating decision making tools that index cumulative exposure to pollutants and health outcomes, refining beta versions of these tools and implementing new efforts to train agency staff in their use. We will also work with the UNC Office of Technology Development to assist researchers in the commercialization process. In addition, the RTC will continue and expand its teacher professional development activities, enabling us to effectively share Superfund related science with broad audiences in appropriate ways. We will also conduct short courses on research translation topics for Environmental Sciences and Engineering students.

Public Health Relevance

RTC activities will enhance the capacity of federal/state/local agencies to provide technical assistance in communities with identified environmental health concerns. We will contribute to the development of improved decision support tools and cleanup technologies. We will also introduce teachers and others to environmental health concepts, preparing them and their students to make informed decisions in their lives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES005948-19
Application #
8378076
Study Section
Special Emphasis Panel (ZES1-LWJ-V)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
19
Fiscal Year
2012
Total Cost
$284,339
Indirect Cost
$95,675
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Martin, Elizabeth M; St├Żblo, Miroslav; Fry, Rebecca C (2017) Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence. Epigenomics 9:701-710
Luo, Yu-Syuan; Cichocki, Joseph A; McDonald, Thomas J et al. (2017) Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatog J Toxicol Environ Health A 80:513-524
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Gao, Lina; Mutlu, Esra; Collins, Leonard B et al. (2017) DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. Chem Res Toxicol 30:794-803
Nakamura, Jun; Shimomoto, Takasumi; Collins, Leonard B et al. (2017) Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes. Sci Rep 7:10787
Brooks, Samira A; Fry, Rebecca C (2017) Cadmium inhibits placental trophoblast cell migration via miRNA regulation of the transforming growth factor beta (TGF-?) pathway. Food Chem Toxicol 109:721-726

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