The Research Translation Core (RTC) focuses on improving scientific and public understanding of how Superfund chemicals harm human health and how to reduce exposure to those chemicals, enabling government officials and the public to make informed decisions about reducing risk. We emphasize the high priority Superfund chemicals studied within the UNC SRP. The RTC aims to: (1) foster and coordinate research translation efforts within UNC SRP and share our results with NIEHS and other SRPs, (2) raise awareness of UNC SRP research among federal, state and local government agencies and build their capacity to protect health and the environment around contaminated sites;(3) advance the practical contributions of our research through development of decision support tools and innovative environmental technology;(4) raise awareness among teachers and other broad audiences of UNC SRP research findings and general environmental health concepts related to hazardous chemical exposure;and (5) increase our students'knowledge of research translation concepts. The RTC will continue current efforts to raise awareness of UNC SRP research and extend them to new state agency partners. We will also implement new initiatives designed to respond to research needs identified by state agencies and local health departments in communities with hazardous waste sites. The RTC will continue to assist NCDENR and NCDHHS in creating decision making tools that index cumulative exposure to pollutants and health outcomes, refining beta versions of these tools and implementing new efforts to train agency staff in their use. We will also work with the UNC Office of Technology Development to assist researchers in the commercialization process. In addition, the RTC will continue and expand its teacher professional development activities, enabling us to effectively share Superfund related science with broad audiences in appropriate ways. We will also conduct short courses on research translation topics for Environmental Sciences and Engineering students.

Public Health Relevance

RTC activities will enhance the capacity of federal/state/local agencies to provide technical assistance in communities with identified environmental health concerns. We will contribute to the development of improved decision support tools and cleanup technologies. We will also introduce teachers and others to environmental health concepts, preparing them and their students to make informed decisions in their lives.

Agency
National Institute of Health (NIH)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES005948-21S1
Application #
8885022
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
City
Chapel Hill
State
NC
Country
United States
Zip Code
Laine, Jessica E; Bailey, Kathryn A; Rubio-Andrade, Marisela et al. (2015) Maternal arsenic exposure, arsenic methylation efficiency, and birth outcomes in the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Mexico. Environ Health Perspect 123:186-92
Edwards, Sharon E; Maxson, Pamela; Miranda, Marie Lynn et al. (2015) Cadmium levels in a North Carolina cohort: Identifying risk factors for elevated levels during pregnancy. J Expo Sci Environ Epidemiol 25:427-32
Rojas, Daniel; Rager, Julia E; Smeester, Lisa et al. (2015) Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci 143:97-106
Bailey, Kathryn A; Fry, Rebecca C (2014) Arsenic-Associated Changes to the Epigenome: What Are the Functional Consequences? Curr Environ Health Rep 1:22-34
Hu, Jing; Adrion, Alden C; Nakamura, Jun et al. (2014) Bioavailability of (Geno)toxic Contaminants in Polycyclic Aromatic Hydrocarbon-Contaminated Soil Before and After Biological Treatment. Environ Eng Sci 31:176-182
Chiu, Weihsueh A; Campbell Jr, Jerry L; Clewell 3rd, Harvey J et al. (2014) Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse. Environ Health Perspect 122:456-63
Rusyn, Ivan; Lemon, Stanley M (2014) Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies? Cancer Lett 345:210-5
Lu, Sixin S; Sobus, Jon R; Sallsten, Gerd et al. (2014) Are urinary PAHs biomarkers of controlled exposure to diesel exhaust? Biomarkers 19:332-9
Nakamura, Jun; Mutlu, Esra; Sharma, Vyom et al. (2014) The endogenous exposome. DNA Repair (Amst) 19:3-13
Mishamandani, Sara; Gutierrez, Tony; Aitken, Michael D (2014) DNA-based stable isotope probing coupled with cultivation methods implicates Methylophaga in hydrocarbon degradation. Front Microbiol 5:76

Showing the most recent 10 out of 329 publications