The purpose of the Research Translafion Core is to make research outcomes available to governmental organ-izafions responsible for protecfing the health of local communities, to the scientific community in general, and to other SRPs in particular. This is in addifion to organizations engaged with the BU SRP through the Community Engagement Core. The principal goal is to provide knowledge of exposure and health effects useful in risk assessment needed for consequenfial decision-making. This proposal builds on our previous work and includes new partners who can use the SRP and Project results for assessment, regulafion and reducfion of con-taminants found at hazardous waste sites.
Specific Aim 1 : Coordinate communicafion of research within BU SRP, in New England, and the larger NIEHS SRP community to improve applicafion of findings, provide access to data, consolidate resources and increase producfivity and collaboration.
Specific Aim 2 : Develop and. maintain partnerships with governmental environmental and public health agencies and provide them with data and expertise that might improve risk assessment-based decisions, particularly with respect to developmental and reproducfive effects of environmental chemicals.
Specific Aim 3 : Effect technology transfer by identifying potenfial end-users of technologies, assays and re^ sources developed by BU SRP projects and facilitate their application.
Specific Aim 4 : Pursue, inifiate and implement Center-specific research translafion activifies (i.e., emanafing from the BU SRP), working with the Community Engagement and Training Cores to have a broader impact.
Our emphasis on open access and the willingness of our investigators to share reagents, new analytic methods, risk assessment techniques, and software, have contributed to the confidence in our partners of our commitment to make our work available to agencies and individuals who must make difficult decisions each day to improve public health and protect the lives of residents living in proximity to hazardous waste sites.
|Aschengrau, Ann; Gallagher, Lisa G; Winter, Michael et al. (2018) Modeled exposure to tetrachloroethylene-contaminated drinking water and the occurrence of birth defects: a case-control study from Massachusetts and Rhode Island. Environ Health 17:75|
|Weisskopf, Marc G; Seals, Ryan M; Webster, Thomas F (2018) Bias Amplification in Epidemiologic Analysis of Exposure to Mixtures. Environ Health Perspect 126:047003|
|Narasimhan, Supraja; Stanford Zulick, Elizabeth; Novikov, Olga et al. (2018) Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Int J Mol Sci 19:|
|Rothhammer, Veit; Borucki, Davis M; Kenison, Jessica E et al. (2018) Detection of aryl hydrocarbon receptor agonists in human samples. Sci Rep 8:4970|
|Lille-Langøy, Roger; Karlsen, Odd André; Myklebust, Line Merethe et al. (2018) Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci :|
|Lemaire, Benjamin; Karchner, Sibel I; Goldstone, Jared V et al. (2018) Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta Proteins Proteom 1866:155-165|
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|Watt, James; Baker, Amelia H; Meeks, Brett et al. (2018) Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. J Cell Physiol 233:7007-7021|
|Aschengrau, Ann; Gallagher, Lisa G; Winter, Michael et al. (2018) Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths: a case-control study from Massachusetts and Rhode Island. Environ Health 17:58|
|Kim, Stephanie; Li, Amy; Monti, Stefano et al. (2018) Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 92:2859-2874|
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