The purpose of the Research Translafion Core is to make research outcomes available to governmental organ-izafions responsible for protecfing the health of local communities, to the scientific community in general, and to other SRPs in particular. This is in addifion to organizations engaged with the BU SRP through the Community Engagement Core. The principal goal is to provide knowledge of exposure and health effects useful in risk assessment needed for consequenfial decision-making. This proposal builds on our previous work and includes new partners who can use the SRP and Project results for assessment, regulafion and reducfion of con-taminants found at hazardous waste sites.
Specific Aim 1 : Coordinate communicafion of research within BU SRP, in New England, and the larger NIEHS SRP community to improve applicafion of findings, provide access to data, consolidate resources and increase producfivity and collaboration.
Specific Aim 2 : Develop and. maintain partnerships with governmental environmental and public health agencies and provide them with data and expertise that might improve risk assessment-based decisions, particularly with respect to developmental and reproducfive effects of environmental chemicals.
Specific Aim 3 : Effect technology transfer by identifying potenfial end-users of technologies, assays and re^ sources developed by BU SRP projects and facilitate their application.
Specific Aim 4 : Pursue, inifiate and implement Center-specific research translafion activifies (i.e., emanafing from the BU SRP), working with the Community Engagement and Training Cores to have a broader impact.

Public Health Relevance

Our emphasis on open access and the willingness of our investigators to share reagents, new analytic methods, risk assessment techniques, and software, have contributed to the confidence in our partners of our commitment to make our work available to agencies and individuals who must make difficult decisions each day to improve public health and protect the lives of residents living in proximity to hazardous waste sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES007381-18
Application #
8659413
Study Section
Special Emphasis Panel (ZES1-JAB-J)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
18
Fiscal Year
2014
Total Cost
$170,673
Indirect Cost
$63,538
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Carwile, Jenny L; Mahalingaiah, Shruthi; Winter, Michael R et al. (2014) Prenatal drinking-water exposure to tetrachloroethylene and ischemic placental disease: a retrospective cohort study. Environ Health 13:72
Lowe, Margaret M; Mold, Jeff E; Kanwar, Bittoo et al. (2014) Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9:e87877
Hoffman, Kate; Vieira, Veronica M; Daniels, Julie L (2014) Brief report: diminishing geographic variability in autism spectrum disorders over time? J Autism Dev Disord 44:712-8
Parks, Ashley J; Pollastri, Michael P; Hahn, Mark E et al. (2014) In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86:593-608
Morrison, Ann Michelle Stanley; Goldstone, Jared V; Lamb, David C et al. (2014) Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14*-demethylase. Biochim Biophys Acta 1840:1825-36
Pillai, Hari K; Fang, Mingliang; Beglov, Dmitri et al. (2014) Ligand binding and activation of PPAR? by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122:1225-32
Reitzel, Adam M; Karchner, Sibel I; Franks, Diana G et al. (2014) Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol 14:6
Bristow, Robert E; Chang, Jenny; Ziogas, Argyrios et al. (2014) Spatial analysis of adherence to treatment guidelines for advanced-stage ovarian cancer and the impact of race and socioeconomic status. Gynecol Oncol 134:60-7
Quintana, Francisco J; Sherr, David H (2013) Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev 65:1148-61
Fraccalvieri, Domenico; Soshilov, Anatoly A; Karchner, Sibel I et al. (2013) Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52:714-25

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