Project 2 evaluates advanced methods for analyzing patterns in epidemiologic and toxicologic data involving combinations of space and time or combinations of chemicals (mixtures). Two SRP mandates are addressed: (1) advanced technicues to detect associations between human health effects and environmental hazards;(2) methods to assess the risks to human health presented by hazardous substances. There are four related research aims and one research translation aim.
Aim 1 is a rigorous evaluation of the use of tensor product smooths in generalized additive models (GAMs) to analyze spacetime interactions in epidemiological data. GAMs predict local disease odds over time while adjusting for known risk factors in the population.
Aim 2 will apply GAM methods to investigate patterns in space and time for two populations: birth defects in parts of Massachusetts and Rhode Island (formal collaboration with SRP Project 1), and Attention Deficit Hyperactivity Disorder (ADHD)-related behaviors in children born while their mothers were living near the New Bedford Harbor Superfund Site.
Aim 3 extends the application of our spatial methods to the analysis of chemical mixtures (formal collaboration with SRP Projects 4 and 6).
In Aim 4, we assess combinations of exposures in epidemiology, adapting methods from toxicology.
Aim 5 will make the methods developed in our project freely available via open source software, in collaboration with the Research Translation Core. The novel methods from this project should be of interest to academia, government and community organizations.
As geographic data become more available, methods that appropriately account for where and when people are exposed become more important. This problem shares certain features with analyzing the effects of mixtures of chemicals, a difficult problem in risk assessment. Our study fills an important gap by rigorously analyzing a promising new technique for theoretical performance and with real world data.
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|Weisskopf, Marc G; Seals, Ryan M; Webster, Thomas F (2018) Bias Amplification in Epidemiologic Analysis of Exposure to Mixtures. Environ Health Perspect 126:047003|
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|Aschengrau, Ann; Gallagher, Lisa G; Winter, Michael et al. (2018) Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths: a case-control study from Massachusetts and Rhode Island. Environ Health 17:58|
|Kim, Stephanie; Li, Amy; Monti, Stefano et al. (2018) Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 92:2859-2874|
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