Project 2 evaluates advanced methods for analyzing patterns in epidemiologic and toxicologic data involving combinations of space and time or combinations of chemicals (mixtures). Two SRP mandates are addressed: (1) advanced technicues to detect associations between human health effects and environmental hazards;(2) methods to assess the risks to human health presented by hazardous substances. There are four related research aims and one research translation aim.
Aim 1 is a rigorous evaluation of the use of tensor product smooths in generalized additive models (GAMs) to analyze spacetime interactions in epidemiological data. GAMs predict local disease odds over time while adjusting for known risk factors in the population.
Aim 2 will apply GAM methods to investigate patterns in space and time for two populations: birth defects in parts of Massachusetts and Rhode Island (formal collaboration with SRP Project 1), and Attention Deficit Hyperactivity Disorder (ADHD)-related behaviors in children born while their mothers were living near the New Bedford Harbor Superfund Site.
Aim 3 extends the application of our spatial methods to the analysis of chemical mixtures (formal collaboration with SRP Projects 4 and 6).
In Aim 4, we assess combinations of exposures in epidemiology, adapting methods from toxicology.
Aim 5 will make the methods developed in our project freely available via open source software, in collaboration with the Research Translation Core. The novel methods from this project should be of interest to academia, government and community organizations.

Public Health Relevance

As geographic data become more available, methods that appropriately account for where and when people are exposed become more important. This problem shares certain features with analyzing the effects of mixtures of chemicals, a difficult problem in risk assessment. Our study fills an important gap by rigorously analyzing a promising new technique for theoretical performance and with real world data.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES007381-18S1
Application #
8908682
Study Section
Special Emphasis Panel (ZES1-JAB-J)
Program Officer
Henry, Heather F
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
18
Fiscal Year
2014
Total Cost
$4,867
Indirect Cost
$1,894
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
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Aschengrau, Ann; Gallagher, Lisa G; Winter, Michael et al. (2018) Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths: a case-control study from Massachusetts and Rhode Island. Environ Health 17:58
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