Understanding the cellular and molecular mechanisms of hazardous chemicals in our environment is a critical national objective. Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA) was established to gain knowledge on the public health risks associated with exposure to Superfund site hazardous waste. Thus, a greater understanding of the exposure pathways and the health consequences resulting from human exposure to uncontrolled hazardous waste from Superfund and other hazardous waste sites are high priorities. The University of Californian at San Diego (UCSD) Superfund Research Program (SRP) Center's objective is to generate new perspectives on the molecular and genetic basis of the biological effects of toxicant exposure, leading to new methodologies for gauging health risks and assessing health effects;innovative detection and monitoring systems for toxicity;and novel models for bioremediation. Our findings have shown that chemical exposure leads to alterations in patterns of gene expression which are controlled and regulated by underlying signal transduction pathways. The investigators will test the hypothesis that "Alterations in biological response by Superfund site chemicals can be exploited to develop models for the detection and bioremediation of chemical toxicants". The UCSD SRP Center has developed a multidisciplinary effort consisting of six biomedical research projects, two non-biomedical research projects, two research support cores and Research Translation and Community Engagement cores. The research will be supported in part by a Ph.D. training program. The environmental problems unique to our coastal environment proximate to the populous U.S.-Mexico border create issues involving water born pollutants that are of special relevance. Through our Research Translation and Community Engagement cores, partnerships have been formed with local industry and community groups to utilize our developing technologies as applied biological tools for assessment of exposure levels and to predict health risk. Investigators with complimentary expertise from ten UCSD Departments, Organized Research Units and Centers are participating in this project, as well as two outside organizations. Our combined efforts are anticipated to provide new insights into the molecular mechanisms that lead to environmental illness, and improve our understanding of the consequences of exposure to Superfund site contaminants.

Public Health Relevance

The UCSD SRP addresses each of the 4 mandates outlined in the Superfund Amendment Act. With the support of our cores, the biomedical programs are working to meet mandates 1 and 2 by developing a better understanding of the impact of toxicants on human health through the creation of models of exposure Mandates 3 and 4 are attained through the work of our non-biomedical projects, which focus on detecting the toxicity of environmental hazards and how to reduce their impact on the environment and human health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
Application #
Study Section
Special Emphasis Panel ()
Program Officer
Henry, Heather F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Patel, Niraj S; Doycheva, Iliana; Peterson, Michael R et al. (2015) Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 13:561-568.e1
Seki, Ekihiro; Schwabe, Robert F (2015) Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology 61:1066-79
Fan, Weiwei; Evans, Ronald (2015) PPARs and ERRs: molecular mediators of mitochondrial metabolism. Curr Opin Cell Biol 33:49-54
Yang, Ling; Roh, Yoon Seok; Song, Jingyi et al. (2014) Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology 59:483-95
Kunz, Hans-Henning; Gierth, Markus; Herdean, Andrei et al. (2014) Plastidial transporters KEA1, -2, and -3 are essential for chloroplast osmoregulation, integrity, and pH regulation in Arabidopsis. Proc Natl Acad Sci U S A 111:7480-5
Schnabl, Bernd; Brenner, David A (2014) Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146:1513-24
Maruo, Yoshihiro; Morioka, Yoriko; Fujito, Hiroshi et al. (2014) Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice. J Pediatr 165:36-41.e1
Dowding, J M; Song, W; Bossy, K et al. (2014) Cerium oxide nanoparticles protect against A?-induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ 21:1622-32
Roybal, Lacey L; Hambarchyan, Arpi; Meadows, Jason D et al. (2014) Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSH?. Mol Endocrinol 28:1640-55
Nakagawa, Hayato; Umemura, Atsushi; Taniguchi, Koji et al. (2014) ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell 26:331-43

Showing the most recent 10 out of 221 publications