? ? This conference will bring together experts in structural biology, bioinorganic chemistry and environmental toxicology of copper, zinc, iron, nickel and arsenic. Translational research relating to the genetics and clinical aspects of metabolic disease involving abnormalities of the handling of these metals will be emphasized. As the third in a series of conferences devoted to advances in research relating to metals and genetics held at the Hospital for Sick Children in Toronto since 1994, this conference will focus on the most recent research developments. Issues relating to the environmental contamination and child health in the developing world will receive special attention. This conference will also pay tribute to the research interests and scientific contributions of Bibudhendra Sarkar, Emeritus Professor of Biochemistry at the University of Toronto, a pioneer in the field of bioinorganic chemistry and translational research relating to metabolic disease. This conference is highly relevant to the SBRP because it address key issues relating to environmental health sciences and, by bringing together a diverse group of scientists and clinician-investigators, it will foster multidisciplinary, translational research. Extended abstracts of the conference will be published in The Journal of Clinical Biochemistry. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES010344-05S1
Application #
6863351
Study Section
Special Emphasis Panel (ZES1-SET-A (S1))
Program Officer
Thompson, Claudia L
Project Start
2000-06-01
Project End
2005-05-24
Budget Start
2004-05-25
Budget End
2005-05-24
Support Year
5
Fiscal Year
2004
Total Cost
$15,000
Indirect Cost
Name
New York University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Niu, Yingmei; DesMarais, Thomas L; Tong, Zhaohui et al. (2015) Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med 82:22-8
Brocato, Jason; Hernandez, Michelle; Laulicht, Freda et al. (2015) In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes. J Toxicol Environ Health A 78:1421-36
Brocato, Jason; Chen, Danqi; Liu, Jianli et al. (2015) A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA. Biol Trace Elem Res 166:72-81
Brocato, Jason; Costa, Max (2015) SATB1 and 2 in colorectal cancer. Carcinogenesis 36:186-91
Brocato, Jason; Wu, Fen; Chen, Yu et al. (2015) Association between sleeping hours and cardiometabolic risk factors for metabolic syndrome in a Saudi Arabian population. BMJ Open 5:e008590
Brocato, Jason; Chervona, Yana; Costa, Max (2014) Molecular responses to hypoxia-inducible factor 1? and beyond. Mol Pharmacol 85:651-7
Brocato, Jason; Fang, Lei; Chervona, Yana et al. (2014) Arsenic induces polyadenylation of canonical histone mRNA by down-regulating stem-loop-binding protein gene expression. J Biol Chem 289:31751-64
Brocato, Jason; Costa, Max (2013) Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol 43:493-514
Arita, Adriana; Muñoz, Alexandra; Chervona, Yana et al. (2013) Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects. Cancer Epidemiol Biomarkers Prev 22:261-9
Passantino, Lisa; Muñoz, Alexandra B; Costa, Max (2013) Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells. Metallomics 5:1357-67

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