The goal of Project 2 is to address several questions concerning the health effects of exposure to arsenic and manganese in water (WAs and WMn, respectively) among adolescents. First, does the As-induced respiratory disease observed in adults also manifest itself in adolescents, and what are possible physiologic mechanisms? Second, to what extent do associations between WAs and both lung function brain function reflect the effects of exposure in utero and in infancy, periods of dramatic development for these systems? Third, are WAs and WMn associated with specific cognitive functions in addition to intelligence? We will draw on an existing sample of 780 adolescents (15-17 years old) whose mothers are participants in the HEALS Study. Based on mothers'well As, measured five times from 2000 until the present, we are able to define four groups of adolescents with varying levels and patterns of exposure to As. Defined on the basis of WAs levels, four groups include adolescents with exposures that are: Group 1) consistently low (mean WAs = 3 ppb);Group 2) consistently moderate (mean WAs = 26 ppb);Group 3) consistently high (mean WAs = 146 ppb);and Group 4) high from conception through roughly age one (mean WAs = 201 ppb) but much lower thereafter (mean WAs =13 ppb). Within each group, there is wide variation in WMn concentrations.
Three specific aims target As exposure and pulmonary function (FEV1 and FVC) as well as biomarkers of lung dysfunction in exhaled breath condensate. Three additional aims expand our earlier work on As, Mn and neuropsychologic outcomes by considering components of Executive Function (planning, sustained attention, working memory) that have been mapped to brain regions thought to be affected by exposure to these elements. Components of Executive Function will be measured with the Cambridge Neuropsychological Test Automated Battery (CANTAB), a computerized and well validated set of tests;intelligence will also be assessed. We will examine adolescents, an understudied age group, because certain components of Executive Function and lung development do not mature until this age;studies with younger children would miss these health effects.
The contamination of water and aquifer sediments with As, and to a lesser extent Mn, are associated with major public health, remedial, legal and environmental policy problems in the United States. Potential exposure to and remediation of both As and Mn represents a significant problem at many Superfund sites. The health effects on adolescents of exposure to these elements are not adequately defined. This project offers an opportunity to elucidate dose-response relationships between exposure and lung and brain function.
|Sun, Jing; Mailloux, Brian J; Chillrud, Steven N et al. (2018) Simultaneously Quantifying Ferrihydrite and Goethite in Natural Sediments Using the Method of Standard Additions with X-ray Absorption Spectroscopy. Chem Geol 476:248-259|
|Argos, Maria; Tong, Lin; Roy, Shantanu et al. (2018) Screening for gene-environment (G×E) interaction using omics data from exposed individuals: an application to gene-arsenic interaction. Mamm Genome 29:101-111|
|Wu, Fen; Chi, Liang; Ru, Hongyu et al. (2018) Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults. Environ Health Perspect 126:017005|
|Sanchez, Tiffany R; Powers, Martha; Perzanowski, Matthew et al. (2018) A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease? Curr Environ Health Rep 5:244-254|
|Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296|
|Sanchez, Tiffany R; Slavkovich, Vesna; LoIacono, Nancy et al. (2018) Urinary metals and metal mixtures in Bangladesh: Exploring environmental sources in the Health Effects of Arsenic Longitudinal Study (HEALS). Environ Int 121:852-860|
|Spratlen, Miranda J; Grau-Perez, Maria; Umans, Jason G et al. (2018) Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study. Environ Int 121:728-740|
|Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129|
|Oliver-Williams, Clare; Howard, Annie Green; Navas-Acien, Ana et al. (2018) Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians. J Am Soc Hypertens 12:426-437.e9|
|Jones, Miranda R; Tellez-Plaza, Maria; Vaidya, Dhananjay et al. (2018) Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA). J Expo Sci Environ Epidemiol :|
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