The goal of Project 4 is to elucidate the separate and combined effects of nanomaterial-based processes and microbial degradation on transformations of target Superfund chemicals, to better understand how nanomaterial-based remediation technologies might be best applied and, to achieve a maximum reduction in toxicity using combined nano-bio remediation. In addition, we seek to understand the potential impacts of nanomaterials themselves on the microbial ecology in sediments. The target contaminants for this study include an organophosphate insecticide (chlorpyrifos), a representative polycyclic aromatic hydrocarbon (benzo[a]pyrene), and a polybrominated flame retardant (decabrominated diphenyl ether, BDE-209). The pervasiveness of these compounds has resulted in a significant need for remediation-strategies to ameliorate their toxicity;however, care must be taken to ensure that remediation techniques do not result in increased toxicity or adverse effects from the use of the technology and/or the degradation products. This project studies remediation using zero valent iron (ZVI) and titanium dioxide (Ti02) nanomaterials for contaminant degradation. Our objectives are to: 1) Investigate the use of nanomaterials as catalysts for direct treatment of sediment and water contaminated by developmental toxicants;2) Assess microbial degradation of the target contaminants by sediment microorganisms with and without nanomaterials;and 3) Uncover possible synergies (or unintended antagonistic effects) of nanoparticle-based remediation with natural microbial degradation processes.

Public Health Relevance

This project will provide guidance for the possible application of TiO2 or ZVI nanoparticles in remediating contaminated sites to achieve long-term degradation of targeted compounds through source treatment combined with in-situ natural attenuation, as well as treatment of dredged material.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
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Duke University
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Raftery, Tara D; Jayasundara, Nishad; Di Giulio, Richard T (2017) A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae. Comp Biochem Physiol C Toxicol Pharmacol 192:23-32
Mu, Jingli; Chernick, Melissa; Dong, Wu et al. (2017) Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes). Aquat Toxicol 190:162-173
Slotkin, Theodore A; Skavicus, Samantha; Card, Jennifer et al. (2017) In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. Toxicology 377:49-56
Luz, Anthony L; Godebo, Tewodros R; Smith, Latasha L et al. (2017) Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. Toxicology 387:81-94
Hartman, Jessica H; Kozal, Jordan S; Di Giulio, Richard T et al. (2017) Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like. Environ Toxicol Pharmacol 54:142-145
Meyer, Joel N; Chan, Sherine S L (2017) Sources, mechanisms, and consequences of chemical-induced mitochondrial toxicity. Toxicology 391:2-4
Slotkin, Theodore A; Skavicus, Samantha; Seidler, Frederic J (2017) Diazinon and parathion diverge in their effects on development of noradrenergic systems. Brain Res Bull 130:268-273
Lindberg, C D; Jayasundara, N; Kozal, J S et al. (2017) Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus. Ecotoxicology 26:435-448
Abreu-Villa├ža, Yael; Levin, Edward D (2017) Developmental neurotoxicity of succeeding generations of insecticides. Environ Int 99:55-77
Jayasundara, Nishad; Fernando, Pani W; Osterberg, Joshua S et al. (2017) Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus. Environ Sci Technol 51:8763-8772

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